AJP - Renal Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Renal Physiol 264: F989-F995, 1993;
0363-6127/93 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Paxton, W. G.
Right arrow Articles by Bernstein, K. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Paxton, W. G.
Right arrow Articles by Bernstein, K. E.

AJP - Renal Physiology, Vol 264, Issue 6 989-F995, Copyright © 1993 by American Physiological Society

ARTICLES

Immunohistochemical localization of rat angiotensin II AT1 receptor

W. G. Paxton, M. Runge, C. Horaist, C. Cohen, R. W. Alexander and K. E. Bernstein
Department of Pathology, Emory University, Atlanta, Georgia 30322.

To study receptors for angiotensin II, polyclonal rabbit anti-peptide antisera were prepared against the peptide QDDCPKAGRHC corresponding to amino acids 15-24 of the rat AT1A and AT1B receptors. Western analysis of rat tissues showed a major band of approximately 43 kDa. The antisera immunoprecipitated AT1-receptor protein produced in vitro. Immunohistochemical analysis of rat tissues showed intense staining of arterial and arteriolar smooth muscle. Other tissues that contained AT1-receptor protein included hepatocytes, the zona glomerulosa of the adrenal gland, and the smooth muscle of the bronchus, gut, ureter, and epididymis. In the kidney, intense staining was observed in all small arteries and arterioles. Both afferent and efferent arterioles contain approximately equal intensities of immunoreactive AT1 protein. The inner stripe of the outer medulla has a moderate level of receptors within thick ascending limb epithelium. Proximal tubular epithelium also expresses receptor protein. Glomerular immunoreactive AT1 protein is found within mesangial cells and varies in intensity among different rat strains. Lewis and Wistar rats demonstrated moderate glomerular staining, whereas the CD and Sprague-Dawley strains showed lesser levels of reactivity. The fact that glomerular mesangial cells are the primary locus of angiotensin II action within the glomerulus.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Renal Physiol.Home page
M. Franco, F. Martinez, B. Rodriguez-Iturbe, R. J. Johnson, J. Santamaria, A. Montoya, T. Nepomuceno, R. Bautista, E. Tapia, and J. Herrera-Acosta
Angiotensin II, interstitial inflammation, and the pathogenesis of salt-sensitive hypertension
Am J Physiol Renal Physiol, December 1, 2006; 291(6): F1281 - F1287.
[Abstract] [Full Text] [PDF]

Home page
 Journal of Renin-Angiotensin-Aldosterone SystemHome page
H. Haller, J.-K. Park, C. Lindschau, M. Meyer, and J. Menne
Intrarenal renin-angiotensin system -- important player of the local milieu
Journal of Renin-Angiotensin-Aldosterone System, June 1, 2006; 7(2): 122 - 125.
[PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
N. Lerolle, S. Bourgeois, F. Leviel, G. Lebrun, M. Paillard, and P. Houillier
Angiotensin II inhibits NaCl absorption in the rat medullary thick ascending limb
Am J Physiol Renal Physiol, September 1, 2004; 287(3): F404 - F410.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
T. H. Le, M. I. Oliverio, H.-S. Kim, H. Salzler, R. C. Dash, D. N. Howell, O. Smithies, S. Bronson, and T. M. Coffman
A {gamma}GT-AT1A receptor transgene protects renal cortical structure in AT1 receptor-deficient mice
Physiol Genomics, August 11, 2004; 18(3): 290 - 298.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
T.-H. Kwon, J. Nielsen, Y.-H. Kim, M. A. Knepper, J. Frokiaer, and S. Nielsen
Regulation of sodium transporters in the thick ascending limb of rat kidney: response to angiotensin II
Am J Physiol Renal Physiol, July 1, 2003; 285(1): F152 - F165.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
L. M. Harrison-Bernard, A. K. Cook, M. I. Oliverio, and T. M. Coffman
Renal segmental microvascular responses to ANG II in AT1A receptor null mice
Am J Physiol Renal Physiol, March 1, 2003; 284(3): F538 - F545.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
H. Okada, T. Inoue, Y. Kanno, T. Kobayashi, Y. Watanabe, J. B. Kopp, R. M. Carey, and H. Suzuki
Interstitial Fibroblast-Like Cells Express Renin-Angiotensin System Components in a Fibrosing Murine Kidney
Am. J. Pathol., March 1, 2002; 160(3): 765 - 772.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
L. G. Navar, L. M. Harrison-Bernard, A. Nishiyama, and H. Kobori
Regulation of Intrarenal Angiotensin II in Hypertension
Hypertension, February 1, 2002; 39(2): 316 - 322.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
E. Feraille and A. Doucet
Sodium-Potassium-Adenosinetriphosphatase-Dependent Sodium Transport in the Kidney: Hormonal Control
Physiol Rev, January 1, 2001; 81(1): 345 - 418.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
K. H. Yoo, B. A. Thornhill, and R. L. Chevalier
Angiotensin stimulates TGF-beta 1 and clusterin in the hydronephrotic neonatal rat kidney
Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2000; 278(3): R640 - R645.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
M. I. Oliverio, C. F. Best, O. Smithies, and T. M. Coffman
Regulation of Sodium Balance and Blood Pressure by the AT1A Receptor for Angiotensin II
Hypertension, February 1, 2000; 35(2): 550 - 554.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
N. Miyata, F. Park, X. F. Li, and A. W. Cowley Jr.
Distribution of angiotensin AT1 and AT2 receptor subtypes in the rat kidney
Am J Physiol Renal Physiol, September 1, 1999; 277(3): F437 - F446.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
R. L. Chevalier, B. A. Thornhill, and J. T. Wolstenholme
Renal cellular response to ureteral obstruction: role of maturation and angiotensin II
Am J Physiol Renal Physiol, July 1, 1999; 277(1): F41 - F47.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
D. W. Good, T. George, and D. H. Wang
Angiotensin II inhibits HCO-3 absorption via a cytochrome P-450-dependent pathway in MTAL
Am J Physiol Renal Physiol, May 1, 1999; 276(5): F726 - F736.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
H. Matsubara
Pathophysiological Role of Angiotensin II Type 2 Receptor in Cardiovascular and Renal Diseases
Circ. Res., December 14, 1998; 83(12): 1182 - 1191.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
T. Hussain, R. Abdul-Wahab, D. K. Kotak, and M. F. Lokhandwala
Bromocriptine Regulates Angiotensin II Response on Sodium Pump in Proximal Tubules
Hypertension, December 1, 1998; 32(6): 1054 - 1059.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
E. H. Nora, D. H. Munzenmaier, F. M. Hansen-Smith, J. H. Lombard, and A. S. Greene
Localization of the ANG II type 2 receptor in the microcirculation of skeletal muscle
Am J Physiol Heart Circ Physiol, October 1, 1998; 275(4): H1395 - H1403.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
D. H. Wang, J. Qiu, and Z. Hu
Differential Regulation of Angiotensin II Receptor Subtypes in the Adrenal Gland : Role of Aldosterone
Hypertension, July 1, 1998; 32(1): 65 - 70.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
C. Grupp, M. Begher, D. Cohen, M. Raghunath, H.-E. Franz, and G. A. Muller
Isolation and characterization of the lower portion of the thin limb of Henle in primary culture
Am J Physiol Renal Physiol, April 1, 1998; 274(4): F775 - F782.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
H.-F. Cheng, J.-L. Wang, G. P. Vinson, and R. C. Harris
Young SHR express increased type 1 angiotensin II receptors in renal proximal tubule
Am J Physiol Renal Physiol, January 1, 1998; 274(1): F10 - F17.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
R. Ozono, Z.-Q. Wang, A. F. Moore, T. Inagami, H. M. Siragy, and R. M. Carey
Expression of the Subtype 2 Angiotensin (AT2) Receptor Protein in Rat Kidney
Hypertension, November 1, 1997; 30(5): 1238 - 1246.
[Abstract] [Full Text]

Home page
 J. Neurosci.Home page
H. Yang, D. Lu, G. P. Vinson, and M. K. Raizada
Involvement of MAP Kinase in Angiotensin II-Induced Phosphorylation and Intracellular Targeting of Neuronal AT1 Receptors
J. Neurosci., March 1, 1997; 17(5): 1660 - 1669.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
R. F. Badenhop, X. L. Wang, and D. E.L. Wilcken
Association Between an Angiotensinogen Microsatellite Marker in Children and Coronary Events in Their Grandparents
Circulation, June 15, 1996; 93(12): 2092 - 2096.
[Abstract] [Full Text]

Home page
 HypertensionHome page
N. Bouby, L. Bankir, and C. Llorens-Cortes
Type 1 Angiotensin II Receptor Subtypes in Kidney of Normal and Salt-Sensitive Hypertensive Rats
Hypertension, March 1, 1996; 27(3): 392 - 398.
[Abstract] [Full Text]

Home page
 Circ. Res.Home page
M. Ishida, M. B. Marrero, B. Schieffer, T. Ishida, K. E. Bernstein, and B. C. Berk
Angiotensin II Activates pp60c-src in Vascular Smooth Muscle Cells
Circ. Res., December 1, 1995; 77(6): 1053 - 1059.
[Abstract] [Full Text]

Home page
 HypertensionHome page
I. M. Bird, R. A. Word, C. Clyne, J. I. Mason, and W. E. Rainey
Potassium Negatively Regulates Angiotensin II Type 1 Receptor Expression in Human Adrenocortical H295R Cells
Hypertension, June 1, 1995; 25(6): 1129 - 1134.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Renal Physiol.Home page
G. Kovacs, J. Peti-Peterdi, L. Rosivall, and P. D. Bell
Angiotensin II directly stimulates macula densa Na-2Cl-K cotransport via apical AT1 receptors
Am J Physiol Renal Physiol, February 1, 2002; 282(2): F301 - F306.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online