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AJP - Renal Physiology, Vol 266, Issue 2 275-F282, Copyright © 1994 by American Physiological Society
ARTICLES |
A. P. Zou, J. D. Imig, M. Kaldunski, P. R. Ortiz de Montellano, Z. Sui and R. J. Roman
Department of Physiology, Medical College of Wisconsin, Milwaukee 53226.
The present study evaluated the role of endogenous P-450 metabolites of arachidonic acid (AA) on autoregulation of renal blood flow in rats. Whole kidney and cortical blood flows were well autoregulated when renal perfusion pressure was varied from 150 to 100 mmHg. Infusion of 17-octadecynoic acid (17-ODYA) into the renal artery (33 nmol/min) increased cortical and papillary blood flows by 12.6 +/- 2.5 and 26.5 +/- 4.6%, respectively. After 17-ODYA, autoregulation of whole kidney and cortical blood flows was impaired. Intrarenal infusion of miconazole (8 nmol/min) had no effect on autoregulation of whole kidney, cortical, or papillary blood flows. 17-ODYA (1 microM) inhibited the formation of 20-hydroxyeicosatetraenoic acid (20-HETE) and 11,12- and 14,15-epoxyeicosatrienoic acids (EETs) by renal preglomerular microvessels in vitro by 83.7 +/- 7.4% and 89.0 +/- 4.9%, respectively. Miconazole (1 microM) reduced the formation of EETs by 86.4 +/- 5.7%, but it had no effect on the production of 20-HETE. These results suggest that endogenous P-450 metabolites of AA, particularly 20-HETE, may participate in the autoregulation of renal blood flow.
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B. Askari, C. P. Bell-Quilley, D. Fulton, J. Quilley, and J. C. McGiff Analysis of Eicosanoid Mediation of the Renal Functional Effects of Hyperchloremia, J. Pharmacol. Exp. Ther., July 1, 1997; 282(1): 101 - 107. [Abstract] [Full Text]
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D. R. Harder, J. Narayanan, E. K. Birks, J. F. Liard, J. D. Imig, J. H. Lombard, A. R. Lange, and R. J. Roman Identification of a Putative Microvascular Oxygen Sensor Circ. Res., July 1, 1996; 79(1): 54 - 61. [Abstract] [Full Text]
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A.-P. Zou, H. A. Drummond, and R. J. Roman Role of 20-HETE in Elevating Loop Chloride Reabsorption in Dahl SS/Jr Rats Hypertension, March 1, 1996; 27(3): 631 - 635. [Abstract] [Full Text]
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S. Arima, K. Omata, S. Ito, K. Tsunoda, and K. Abe 20-HETE Requires Increased Vascular Tone to Constrict Rabbit Afferent Arterioles Hypertension, March 1, 1996; 27(3): 781 - 785. [Abstract] [Full Text]
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