AJP - Renal Email Content Delivery
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Renal Physiol 266: F291-F297, 1994;
0363-6127/94 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kohan, D. E.
Right arrow Articles by Padilla, E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kohan, D. E.
Right arrow Articles by Padilla, E.

AJP - Renal Physiology, Vol 266, Issue 2 291-F297, Copyright © 1994 by American Physiological Society

ARTICLES

Endothelin-1 production by rat inner medullary collecting duct: effect of nitric oxide, cGMP, and immune cytokines

D. E. Kohan and E. Padilla
Division of Nephrology, Department of Veterans Affairs Medical Center, Salt Lake City, Utah.

Nitric oxide (NO), guanosine 3',5'-cyclic monophosphate (cGMP), and endothelin-1 (ET-1) inhibit collecting duct sodium reabsorption. Because the inner medullary collecting duct (IMCD) synthesizes NO and ET-1, we examined NO and cGMP regulation of IMCD ET-1 production. S-nitroso-N-acetylpenicillamine (SNAP, 6 h) increased NO and cGMP and modestly reduced ET-1 release in cultured rat IMCD. Atrial natriuretic peptide or dibutyryl cGMP (6 h exposure to each) also mildly decreased IMCD ET-1 release. In long-term exposure studies, IMCD cells were incubated with tumor necrosis factor (TNF) and interferon-gamma (IFN) up to 72 h. IFN/TNF increased NO and cGMP production while reducing ET-1 release by 84%; N-monomethyl-L-arginine inhibited this effect only marginally, suggesting NO was not primarily involved. IFN alone greatly reduced IMCD ET-1 release and ET-1 mRNA levels. These data indicate that short- and long-term increases in NO and cGMP modestly reduce IMCD ET-1 production. Additionally, IFN potently inhibits IMCD ET-1 release by an undetermined mechanism.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Renal Physiol.Home page
K. A. Strait, P. K. Stricklett, J. L. Kohan, M. B. Miller, and D. E. Kohan
Calcium regulation of endothelin-1 synthesis in rat inner medullary collecting duct
Am J Physiol Renal Physiol, August 1, 2007; 293(2): F601 - F606.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
G.-F. Chen and Z. Sun
Effects of chronic cold exposure on the endothelin system
J Appl Physiol, May 1, 2006; 100(5): 1719 - 1726.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
J. Zimpelmann, N. Li, and K. D. Burns
Nitric oxide inhibits superoxide-stimulated urea permeability in the rat inner medullary collecting duct
Am J Physiol Renal Physiol, December 1, 2003; 285(6): F1160 - F1167.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
S. Chen, L. Cao, H. D. Intengan, M. Humphreys, and D. G. Gardner
Osmoregulation of Endothelial Nitric-oxide Synthase Gene Expression in Inner Medullary Collecting Duct Cells. ROLE IN ACTIVATION OF THE TYPE A NATRIURETIC PEPTIDE RECEPTOR
J. Biol. Chem., August 30, 2002; 277(36): 32498 - 32504.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
B. Jiang, S. Morimoto, K. Fukuo, A. Hirotani, M. Tamatani, T. Nakahashi, A. Nishibe, T. Niinobu, S. Hata, S. Chen, et al.
Parathyroid Hormone–Related Protein Inhibits Endothelin-1 Production
Hypertension, March 1, 1996; 27(3): 360 - 363.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online