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Am J Physiol Renal Physiol 266: F309-F315, 1994;
0363-6127/94 $5.00
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AJP - Renal Physiology, Vol 266, Issue 2 309-F315, Copyright © 1994 by American Physiological Society

ARTICLES

X-linked hypophosphatemic Gy mice: renal tubular maximum for phosphate vs. brush-border transport after low-P diet

S. W. Thornton, H. S. Tenenhouse, J. Martel, R. W. Bockian, M. H. Meyer and R. A. Meyer Jr
Department of Biology, University of North Carolina at Charlotte 28223.

We examined the effect of the X-linked hypophosphatemic Gy mutation on the maximal renal tubular reabsorption of phosphate (TmP) and compared the effects of phosphate deprivation on both TmP and Na(+)-dependent phosphate transport in renal brush-border membrane vesicles (BBMV). Adult female normal and Gy mice were fed a control (1.0% P) or low-phosphate (0.03% P) diet for 5 days. For TmP measurement, anesthetized mice were infused intravenously with [3H]inulin and increasing increments of phosphate (0, 0.27, 0.54, and 1.08 mumol/min). TmP was significantly reduced in Gy mice on the control diet. Normal mice responded to the low-phosphate diet by raising their TmP [2.35 +/- 0.12 (n = 9) vs. 3.71 +/- 0.16 (n = 9) mumol/ml glomerular filtrate, mean +/- SE, P < 0.001], whereas in Gy mice, the change was not significant [1.46 +/- 0.10 (n = 10) vs. 1.70 +/- 0.11 (n = 10)]. In contrast, Gy mice did respond to phosphate restriction by increasing the initial-rate Na(+)-dependent phosphate transport in the renal BBMV [314 +/- 11 (n = 5) vs. 1,105 +/- 157 (n = 5) pmol.mg protein-1.6 s-1, P < 0.01] as did normal mice [583 +/- 64 (n = 5) vs. 1,692 +/- 203 (n = 5) pmol.mg protein-1.6 s-1, P < 0.01]. In conclusion, the adaptive increase in Na(+)-phosphate cotransport in the brush-border membrane of the proximal tubule is not sufficient for the overall increase in TmP in the whole kidney in response to dietary phosphate deprivation.


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M. H. Meyer, E. Dulde, and R. A. Meyer Jr.
The genomic response of the mouse kidney to low-phosphate diet is altered in X-linked hypophosphatemia
Physiol Genomics, June 17, 2004; 18(1): 4 - 11.
[Abstract] [Full Text] [PDF]


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