AJP - Renal Physiology, Vol 266, Issue 4 517-F527, Copyright © 1994 by American Physiological Society

ARTICLES

Coupling between transepithelial Na transport and basolateral K conductance in renal proximal tubule

J. S. Beck, R. Laprade and J. Y. Lapointe

A common feature of sodium-reabsorbing epithelia is their ability to match salt entry to salt exit. It is recognized that a key strategy to perform this feat involves the coupling between basolateral sodium pump and potassium conductance (pump-leak coupling). In the renal proximal tubule this coupling is of major importance, as regions of this nephron segment are faced with ever-changing reabsorptive loads. An understanding of this coupling can be facilitated by critically examining those studies that have looked at the problem from the point of view of the whole cell (macroscopic studies) and of single channels (microscopic studies). An overview of such work suggests that the transduction mechanisms which are likely to effect pump-leak coupling in the renal proximal tubule involve cell volume, ATP, and pH (but not calcium). Although the relationship between ATP and potassium conductance may be relatively straightforward, the involvement of pH is likely to be only transient and that of volume remains controversial, occurring either directly though stretch-activated channels in amphibian preparations or indirectly through an as yet unidentified second messenger system in mammalian preparations.

This article has been cited by other articles:

				A. M. Weinstein, S. Weinbaum, Y. Duan, Z. Du, Q. Yan, and T. Wang Flow-dependent transport in a mathematical model of rat proximal tubule Am J Physiol Renal Physiol, April 1, 2007; 292(4): F1164 - F1181. [Abstract] [Full Text] [PDF]

				S. C. Hebert, G. Desir, G. Giebisch, and W. Wang Molecular Diversity and Regulation of Renal Potassium Channels Physiol Rev, January 1, 2005; 85(1): 319 - 371. [Abstract] [Full Text] [PDF]

				C. Karle, T. Gehrig, R. Wodopia, S. Hoschele, V. A. W. Kreye, H. A. Katus, P. Bartsch, and H. Mairbaurl Hypoxia-induced inhibition of whole cell membrane currents and ion transport of A549 cells Am J Physiol Lung Cell Mol Physiol, June 1, 2004; 286(6): L1154 - L1160. [Abstract] [Full Text] [PDF]

				S. Muto, Y. Asano, W. Wang, D. Seldin, and G. Giebisch Activity of the basolateral K+ channels is coupled to the Na+-K+-ATPase in the cortical collecting duct Am J Physiol Renal Physiol, November 1, 2003; 285(5): F945 - F954. [Abstract] [Full Text] [PDF]

				Y. Wei and W. Wang Angiotensin II stimulates basolateral K channels in rat cortical collecting ducts Am J Physiol Renal Physiol, January 1, 2003; 284(1): F175 - F181. [Abstract] [Full Text] [PDF]

				P. Gomes and P. Soares-da-Silva D2-like receptor-mediated inhibition of Na+-K+-ATPase activity is dependent on the opening of K+ channels Am J Physiol Renal Physiol, July 1, 2002; 283(1): F114 - F123. [Abstract] [Full Text] [PDF]

				Y. Wei, M. Lu, and W. Wang Ca2+ mediates the effect of inhibition of Na+-K+-ATPase on the basolateral K+ channels in the rat CCD Am J Physiol Cell Physiol, April 1, 2001; 280(4): C920 - C928. [Abstract] [Full Text] [PDF]

				C. U. Cotton Basolateral Potassium Channels and Epithelial Ion Transport Am. J. Respir. Cell Mol. Biol., September 1, 2000; 23(3): 270 - 272. [Full Text]

				J.-F. Noulin, E. Brochiero, J.-Y. Lapointe, and R. Laprade Two types of K+ channels at the basolateral membrane of proximal tubule: inhibitory effect of taurine Am J Physiol Renal Physiol, August 1, 1999; 277(2): F290 - F297. [Abstract] [Full Text] [PDF]

				S. Muto, Y. Asano, D. Seldin, and G. Giebisch Basolateral Na+ pump modulates apical Na+ and K+ conductances in rabbit cortical collecting ducts Am J Physiol Renal Physiol, January 1, 1999; 276(1): F143 - F158. [Abstract] [Full Text] [PDF]

				W. P. Dubinsky, O. Mayorga-Wark, and S. G. Schultz Colocalization of glycolytic enzyme activity and KATP channels in basolateral membrane of Necturus enterocytes Am J Physiol Cell Physiol, December 1, 1998; 275(6): C1653 - C1659. [Abstract] [Full Text] [PDF]

				V. Vallon, M. Albinus, and D. Blach Effect of KATP Channel Blocker U37883A on Renal Function in Experimental Diabetes Mellitus in Rats J. Pharmacol. Exp. Ther., September 1, 1998; 286(3): 1215 - 1221. [Abstract] [Full Text]

				F. LANG, G. L. BUSCH, M. RITTER, H. VOLKL, S. WALDEGGER, E. GULBINS, and D. HAUSSINGER Functional Significance of Cell Volume Regulatory Mechanisms Physiol Rev, January 1, 1998; 78(1): 247 - 306. [Abstract] [Full Text] [PDF]

				E. Brochiero, B. Wallendorf, D. Gagnon, R. Laprade, and J.-Y. Lapointe Cloning of rabbit Kir6.1, SUR2A, and SUR2B: possible candidates for a renal KATP channel Am J Physiol Renal Physiol, February 1, 2002; 282(2): F289 - F300. [Abstract] [Full Text] [PDF]