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Am J Physiol Renal Physiol 266: F674-F680, 1994;
0363-6127/94 $5.00
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AJP - Renal Physiology, Vol 266, Issue 4 674-F680, Copyright © 1994 by American Physiological Society

ARTICLES

Interleukin-1 inhibits sodium and water transport in rabbit cortical collecting duct

Y. Sakairi, Y. Ando, K. Tabei, E. Kusano and Y. Asano
Division of Nephrology, Jichi Medical School Hospital, Tochigi, Japan.

Interleukin-1 (IL-1) induces natriuresis and diuresis. In the present study, the effect of basolateral IL-1 on sodium and water transport was examined in the cortical collecting duct (CCD) perfused in vitro. IL-1, 10 pg/ml and 10 ng/ml, inhibited lumen-to-bath sodium flux (JNa, peq.min-1.mm tubule-1), depolarizing transepithelial voltage (Vt) in a time- and dose-dependent manner. The inhibitory effect of 10 ng/ml but not 10 pg/ml IL-1 on Vt and JNa was mitigated by 5 microM indomethacin (IND) in bath. Also, 10 ng/ml IL-1, which did not affect the basal hydraulic conductivity (Lp, x10(-7) cm.atm-1.s-1) by itself, inhibited the hydrosmotic effect of 20 pM basolateral arginine vasopressin, and 5 microM IND abolished this inhibitory effect of 10 ng/ml IL-1. The present study demonstrated direct inhibitory effect of basolateral IL-1 on sodium and water reabsorption in the rabbit CCD. The effect of IL-1 is suggested to be mediated, in part, by a cyclooxygenase metabolite(s).


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