| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
AJP - Renal Physiology, Vol 266, Issue 5 823-F828, Copyright © 1994 by American Physiological Society
ARTICLES |
Y. Sugimoto, T. Namba, R. Shigemoto, M. Negishi, A. Ichikawa and S. Narumiya
Department of Physiological Chemistry, Faculty of Pharmaceutical Sciences, Kyoto University, Japan.
Distribution of the mRNAs for three subtypes of prostaglandin E (PGE) receptors in the mouse kidney was investigated by in situ hybridization. The mRNA for EP1 subtype, which is coupled to Ca2+ mobilization, was specifically localized to the collecting ducts from the cortex to the papilla. The mRNA for EP2 subtype, which is linked to stimulation of adenylate cyclase, was localized to the glomeruli. The mRNA for EP3 subtype, which is coupled to inhibition of adenylate cyclase, was located densely in the tubules in the outer medulla and in the distal tubules in the cortex. These results exhibit distinct cellular localization of three subtypes of PGE receptor in the kidney and suggest that PGE2 exerts multiple functions via these subtypes expressed in different segments of the nephron.
This article has been cited by other articles:
|
|
 |
|
  R. A. Fenton and M. A. Knepper Mouse Models and the Urinary Concentrating Mechanism in the New Millennium Physiol Rev, October 1, 2007; 87(4): 1083 - 1112. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Bachteeva, E. Fock, E. Lavrova, S. Nikolaeva, S. Gambaryan, and R. Parnova Prostaglandin E2 inhibits vasotocin-induced osmotic water permeability in the frog urinary bladder by EP1-receptor-mediated activation of NO/cGMP pathway Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2007; 293(1): R528 - R537. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Machida, S. Wakamatsu, Y. Izumi, T. Yosifovska, T. Matsuzaki, Y. Nakayama, Y. Kohda, T. Inoue, H. Saito, K. Tomita, et al. Downregulation of the V2 vasopressin receptor in dehydration: mechanisms and role of renal prostaglandin synthesis Am J Physiol Renal Physiol, April 1, 2007; 292(4): F1274 - F1282. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Nasrallah, H. Xiong, and R. L. Hebert Renal prostaglandin E2 receptor (EP) expression profile is altered in streptozotocin and B6-Ins2Akita type I diabetic mice Am J Physiol Renal Physiol, January 1, 2007; 292(1): F278 - F284. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. G. Friis, J. Stubbe, T. R. Uhrenholt, P. Svenningsen, R. M. Nusing, O. Skott, and B. L. Jensen Prostaglandin E2 EP2 and EP4 receptor activation mediates cAMP-dependent hyperpolarization and exocytosis of renin in juxtaglomerular cells Am J Physiol Renal Physiol, November 1, 2005; 289(5): F989 - F997. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. C. Kopp, M. Z. Cicha, K. Nakamura, R. M. Nusing, L. A. Smith, and T. Hokfelt Activation of EP4 receptors contributes to prostaglandin E2-mediated stimulation of renal sensory nerves Am J Physiol Renal Physiol, December 1, 2004; 287(6): F1269 - F1282. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Nasrallah, A. Landry, S. Singh, M. Sklepowicz, and R. L. Hebert Increased expression of cyclooxygenase-1 and -2 in the diabetic rat renal medulla Am J Physiol Renal Physiol, December 1, 2003; 285(6): F1068 - F1077. [Abstract] [Full Text]
|
|
|
|
|
|
O. Saito, Y. Guan, Z. Qi, L. S. Davis, M. Komhoff, Y. Sugimoto, S. Narumiya, R. M. Breyer, and M. D. Breyer Expression of the prostaglandin F receptor (FP) gene along the mouse genitourinary tract Am J Physiol Renal Physiol, June 1, 2003; 284(6): F1164 - F1170. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. I. Lemieux, S. S. Rahal, and C. R. J. Kennedy PGE2 reduces arachidonic acid release in murine podocytes: evidence for an autocrine feedback loop Am J Physiol Cell Physiol, February 1, 2003; 284(2): C302 - C309. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-F. Cheng, S.-W. Wang, M.-Z. Zhang, J. A. McKanna, R. Breyer, and R. C. Harris Prostaglandins that increase renin production in response to ACE inhibition are not derived from cyclooxygenase-1 Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2002; 283(3): R638 - R646. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Imig, M. D. Breyer, and R. M. Breyer Contribution of prostaglandin EP2 receptors to renal microvascular reactivity in mice Am J Physiol Renal Physiol, September 1, 2002; 283(3): F415 - F422. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Asano, J. Shoda, T. Ueda, T. Kawamoto, T. Todoroki, M. Shimonishi, T. Tanabe, Y. Sugimoto, A. Ichikawa, M. Mutoh, et al. Expressions of Cyclooxygenase-2 and Prostaglandin E-Receptors in Carcinoma of the Gallbladder: Crucial Role of Arachidonate Metabolism in Tumor Growth and Progression Clin. Cancer Res., April 1, 2002; 8(4): 1157 - 1167. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Nasrallah, O. Laneuville, S. Ferguson, and R. L. Hebert Effect of COX-2 inhibitor NS-398 on expression of PGE2 receptor subtypes in M-1 mouse CCD cells Am J Physiol Renal Physiol, July 1, 2001; 281(1): F123 - F132. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Takeuchi, H. Araki, M. Umeda, Y. Komoike, and K. Suzuki Adaptive Gastric Cytoprotection Is Mediated by Prostaglandin EP1 Receptors: A Study Using Rats and Knockout Mice J. Pharmacol. Exp. Ther., June 1, 2001; 297(3): 1160 - 1165. [Abstract] [Full Text]
|
|
|
|
|
|
B. L. Jensen, J. Stubbe, P. B. Hansen, D. Andreasen, and O. Skott Localization of prostaglandin E2 EP2 and EP4 receptors in the rat kidney Am J Physiol Renal Physiol, June 1, 2001; 280(6): F1001 - F1009. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Nasrallah, J. Zimpelmann, S. Singh, and R. L. Hebert Molecular and biochemical characterization of prostacyclin receptors in rat kidney Am J Physiol Renal Physiol, February 1, 2001; 280(2): F266 - F277. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L.-J. Dai, G. Ritchie, D. Kerstan, H. S. Kang, D. E. C. Cole, and G. A. Quamme Magnesium Transport in the Renal Distal Convoluted Tubule Physiol Rev, January 1, 2001; 81(1): 51 - 84. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Imig Eicosanoid regulation of the renal vasculature Am J Physiol Renal Physiol, December 1, 2000; 279(6): F965 - F981. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Yang, Y. Endo, Y. G. Huang, A. Smart, J. P. Briggs, and J. Schnermann Renin expression in COX-2-knockout mice on normal or low-salt diets Am J Physiol Renal Physiol, November 1, 2000; 279(5): F819 - F825. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. E. Purdy and W. J. Arendshorst EP1 and EP4 receptors mediate prostaglandin E2 actions in the microcirculation of rat kidney Am J Physiol Renal Physiol, October 1, 2000; 279(4): F755 - F764. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. D. Breyer and R. M. Breyer Prostaglandin E receptors and the kidney Am J Physiol Renal Physiol, July 1, 2000; 279(1): F12 - F23. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Tang, K. Loutzenhiser, and R. Loutzenhiser Biphasic Actions of Prostaglandin E2 on the Renal Afferent Arteriole : Role of EP3 and EP4 Receptors Circ. Res., March 31, 2000; 86(6): 663 - 670. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. J. Millatt and H. M. Siragy Age-Related Changes in Renal Cyclic Nucleotides and Eicosanoids in Response to Sodium Intake Hypertension, February 1, 2000; 35(2): 643 - 647. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. R. Traynor, A. Smart, J. P. Briggs, and J. Schnermann Inhibition of macula densa-stimulated renin secretion by pharmacological blockade of cyclooxygenase-2 Am J Physiol Renal Physiol, November 1, 1999; 277(5): F706 - F710. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Narumiya, Y. Sugimoto, and F. Ushikubi Prostanoid Receptors: Structures, Properties, and Functions Physiol Rev, October 1, 1999; 79(4): 1193 - 1226. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Morris and C. C. Malbon Physiological Regulation of G Protein-Linked Signaling Physiol Rev, October 1, 1999; 79(4): 1373 - 1430. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. BEK, R. NÜSING, P. KOWARK, A. HENGER, P. MUNDEL, and H. PAVENSTÄDT Characterization of Prostanoid Receptors in Podocytes J. Am. Soc. Nephrol., October 1, 1999; 10(10): 2084 - 2093. [Abstract] [Full Text]
|
|
|
|
|
|
R. MORATH, T. KLEIN, H. W. SEYBERTH, and R. M. NÜSING Immunolocalization of the Four Prostaglandin E2 Receptor Proteins EP1, EP2, EP3, and EP4 in Human Kidney J. Am. Soc. Nephrol., September 1, 1999; 10(9): 1851 - 1860. [Abstract] [Full Text]
|
|
|
|
 |
|
 K. Mori, Y. Ogawa, K. Ebihara, N. Tamura, K. Tashiro, T. Kuwahara, M. Mukoyama, A. Sugawara, S. Ozaki, I. Tanaka, et al. Isolation and Characterization of CA XIV, a Novel Membrane-bound Carbonic Anhydrase from Mouse Kidney J. Biol. Chem., May 28, 1999; 274(22): 15701 - 15705. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. F. Fleming, K. Athirakul, M. I. Oliverio, M. Key, J. Goulet, B. H. Koller, and T. M. Coffman Urinary concentrating function in mice lacking EP3 receptors for prostaglandin E2 Am J Physiol Renal Physiol, December 1, 1998; 275(6): F955 - F961. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L.-J. Dai, B. Bapty, G. Ritchie, and G. A. Quamme PGE2 stimulates Mg2+ uptake in mouse distal convoluted tubule cells Am J Physiol Renal Physiol, November 1, 1998; 275(5): F833 - F839. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Schnermann Juxtaglomerular cell complex in the regulation of renal salt excretion Am J Physiol Regulatory Integrative Comp Physiol, February 1, 1998; 274(2): R263 - R279. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Miyaura, M. Inada, T. Suzawa, Y. Sugimoto, F. Ushikubi, A. Ichikawa, S. Narumiya, and T. Suda Impaired Bone Resorption to Prostaglandin E2 in Prostaglandin E Receptor EP4-knockout Mice J. Biol. Chem., June 23, 2000; 275(26): 19819 - 19823. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
