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Am J Physiol Renal Physiol 267: F86-F93, 1994;
0363-6127/94 $5.00
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AJP - Renal Physiology, Vol 267, Issue 1 86-F93, Copyright © 1994 by American Physiological Society

ARTICLES

Active lithium transport by rat renal proximal tubule: a micropuncture study

P. P. Leyssac, O. Frederiksen, N. H. Holstein-Rathlou, A. C. Alfrey and P. Christensen
Department of Medical Physiology, Panum Institute, University of Copenhagen, Denmark.

We tested the hypothesis that proximal tubular Li+ reabsorption is due to passive transport. Clearances of [14C]inulin (CIn) and Li+ (CLi), proximal transepithelial electrical potential difference (PD), and tubular fluid-to-plasma Li+ concentration ratios [(TF/P)Li] were measured in anesthetized rats before and after induction of osmotic mannitol diuresis. Late proximal (TF/P)Li was measured after acute intravenous LiCl administration and after addition of LiCl to the diet for 2 days. Glomerular filtration rate (CIn) decreased, whereas CNa and CLi increased during osmotic diuresis. Control early proximal PD was -0.6 mV (lumen negative); late proximal PD (PDLP) was 1.1 mV (lumen positive). PDLP decreased by 1.5 mV to -0.4 mV (lumen negative) after mannitol infusion. Late proximal (TF/P)Li was 1.01 after oral Li+, 1.16 after intravenous Li+ (P < 0.01), and 1.00 during osmotic diuresis. It is concluded that proximal Li+ transfer is distinct from that of Na+, closely parallels proximal water transfer, and involves an active transport mechanism independent of the PD. The data suggest that acute elevation of plasma Li+ concentration may activate a delayed Li+ transport pathway in the proximal convoluted tubule.


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