| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
AJP - Renal Physiology, Vol 267, Issue 6 1063-F1068, Copyright © 1994 by American Physiological Society
ARTICLES |
M. Brezis, S. N. Heyman and F. H. Epstein
Department of Medicine, Hadassah University Hospital, Mount Scopus, Jerusalem, Israel.
To study hemodynamic effects on intrarenal oxygenation, O2 microelectrodes were inserted into rat kidneys. In a previous study [M. Brezis, Y. Agmon, and F. H. Epstein. Am. J. Physiol. 267 (Renal Fluid Electrolyte Physiol. 36): F1059-F1062, 1994], we showed that tubular metabolism is a major determinant of intrarenal oxygenation, in part responsible for medullary hypoxia observed under basal conditions. Acute hypotension (by controlled hemorrhage, aortic ligation, or nitroprusside infusion) paradoxically increased medullary PO2 (from 21 +/- 2 to 39 +/- 2 mmHg, P < 0.001) while decreasing cortical PO2 (from 46 +/- 2 to 32 +/- 3 mmHg, P < 0.001), abolishing corticomedullary gradients of oxygen. Laser-Doppler studies indicated that, while cortical blood flow was reduced during hypotension, medullary blood flow was unchanged or increased. The increase in medullary PO2 induced by hypotension was abolished by prior administration of furosemide, suggesting that during hypotension, reduced glomerular filtration rate (GFR), distal delivery, and reabsorption result in decreased oxygen utilization. Acute infusions of atriopeptin III (0.1-1 microgram.kg-1.min-1) decreased both cortical PO2 (from 61 +/- 2 to 55 +/- 2 mmHg, P < 0.001) and medullary PO2 (from 15 +/- 1 to 7 +/- 1 mmHg, P < 0.001), consistent with atriopeptin-induced increases in GFR and tubular reabsorptive work. These data suggest that medullary oxygen availability increases during renal hypoperfusion and may decrease during renal vasodilation.
This article has been cited by other articles:
|
|
 |
|
  C.-L. Leong, W. P. Anderson, P. M. O'Connor, and R. G. Evans Evidence that renal arterial-venous oxygen shunting contributes to dynamic regulation of renal oxygenation Am J Physiol Renal Physiol, June 1, 2007; 292(6): F1726 - F1733. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Whitehouse, M. Stotz, V. Taylor, R. Stidwill, and M. Singer Tissue oxygen and hemodynamics in renal medulla, cortex, and corticomedullary junction during hemorrhage-reperfusion Am J Physiol Renal Physiol, September 1, 2006; 291(3): F647 - F653. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. V. Prasad Functional MRI of the kidney: tools for translational studies of pathophysiology of renal disease Am J Physiol Renal Physiol, May 1, 2006; 290(5): F958 - F974. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Johannes, E. G. Mik, and C. Ince Dual-wavelength phosphorimetry for determination of cortical and subcortical microvascular oxygenation in rat kidney J Appl Physiol, April 1, 2006; 100(4): 1301 - 1310. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Balestra, P. Germonpre, J. R. Poortmans, and A. Marroni Serum erythropoietin levels in healthy humans after a short period of normobaric and hyperbaric oxygen breathing: the "normobaric oxygen paradox" J Appl Physiol, February 1, 2006; 100(2): 512 - 518. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Cao, W. Lee-Kwon, E. P. Silldorff, and T. L. Pallone KATP channel conductance of descending vasa recta pericytes Am J Physiol Renal Physiol, December 1, 2005; 289(6): F1235 - F1245. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Lee-Kwon, J. B. Wade, Z. Zhang, T. L. Pallone, and E. J. Weinman Expression of TRPC4 channel protein that interacts with NHERF-2 in rat descending vasa recta Am J Physiol Cell Physiol, April 1, 2005; 288(4): C942 - C949. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. W. Cowley Jr., T. Mori, D. Mattson, and A.-P. Zou Role of renal NO production in the regulation of medullary blood flow Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2003; 284(6): R1355 - R1369. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. L. Mattson Importance of the renal medullary circulation in the control of sodium excretion and blood pressure Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2003; 284(1): R13 - R27. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Zhang and A. Edwards Oxygen transport across vasa recta in the renal medulla Am J Physiol Heart Circ Physiol, September 1, 2002; 283(3): H1042 - H1055. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Adler and H. Huang Impaired Regulation of Renal Oxygen Consumption in Spontaneously Hypertensive Rats J. Am. Soc. Nephrol., July 1, 2002; 13(7): 1788 - 1794. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A.-P. ZOU, Z.-Z. YANG, P.-L. LI, and A. W. COWLEY JR. Oxygen-dependent expression of hypoxia-inducible factor-1{alpha} in renal medullary cells of rats Physiol Genomics, August 28, 2001; 6(3): 159 - 168. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. FLEMMING, E. SEELIGER, T. WRONSKI, K. STEER, N. ARENZ, and P. B. PERSSON Oxygen and Renal Hemodynamics in the Conscious Rat J. Am. Soc. Nephrol., January 1, 2000; 11(1): 18 - 24. [Abstract] [Full Text]
|
|
|
|
|
|
A. D. Baines, G. Adamson, P. Wojciechowski, D. Pliura, P. Ho, and R. Kluger Effect of modifying O2 diffusivity and delivery on glomerular and tubular function in hypoxic perfused kidney Am J Physiol Renal Physiol, April 1, 1998; 274(4): F744 - F752. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Brezis and S. Rosen Hypoxia of the Renal Medulla -- Its Implications for Disease N. Engl. J. Med., March 9, 1995; 332(10): 647 - 655. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
