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Am J Physiol Renal Physiol 267: F931-F936, 1994;
0363-6127/94 $5.00
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AJP - Renal Physiology, Vol 267, Issue 6 931-F936, Copyright © 1994 by American Physiological Society

ARTICLES

Anatomic pairing of afferent arterioles and renin cell distribution in rat kidneys

D. Casellas, M. Dupont, N. Bouriquet, L. C. Moore, A. Artuso and A. Mimran
Groupe Rein et Hypertension, Hopital St. Charles, Montpellier, France.

Close afferent arteriolar (AA) connectivity is a prerequisite for hemodynamic interaction between superficial rat nephrons. Studies were conducted in rat, mouse, rabbit, and human renal vasculatures obtained by an HCl maceration-microdissection technique to document the extent of AA connectivity. In rat kidneys, we assessed the possibility for a slow component of internephron coupling, as reflected by arteriolar renin cell distribution after specific immunostaining for renin. In the four species examined, 51% (human) to 60% (mouse) of total AA populations were organized as vascular units consisting of mostly two AA sharing a common origin and a connecting arterial segment. In rat AA pairs, branch lengths were significantly correlated, suggesting coordinated arteriolar growth. The sum of AA branch lengths averaged 278 +/- 6 microns. Rat arteriolar renin status, ranging from no renin cells to renin-recruited midafferent arterioles, distributed in a significantly nonrandom fashion within AA pairs, and 52% of the pairs had equal renin status. Hence, AA pairing is a consistent anatomic characteristic of mammalian kidneys and may constitute an optimal vascular design for hemodynamic as well as endocrine interactions.


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