AJP - Renal AJP: Regulatory, Integrative and Comparative Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Renal Physiol 270: F356-F370, 1996;
0363-6127/96 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Cortes, P.
Right arrow Articles by Narins, R. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Cortes, P.
Right arrow Articles by Narins, R. G.

AJP - Renal Physiology, Vol 270, Issue 2 356-F370, Copyright © 1996 by American Physiological Society

ARTICLES

Regulation of glomerular volume in normal and partially nephrectomized rats

P. Cortes, X. Zhao, B. L. Riser and R. G. Narins
Department of Internal Medicine, Henry Ford Hospital, Detroit, Michigan 48202, USA.

Glomerular extracellular matrix accumulation may derive from the stretching of mesangial cells caused by excessive glomerular dilatation. The relationship of glomerular volume (VG) to intraglomerular pressure, expressed as compliance or as mean VG in the isolated, perfused rat glomerulus, was used to analyze factors that regulate VG. Glomeruli were highly distensible over the normal and relevant abnormal range of pressure. Compliance increased directly with basal VG (P < 0.001), i.e., larger glomeruli dilated more than smaller ones at any given pressure. Perfusion with atrial natriuretic peptide did not alter compliance, and inhibitors of nitric oxide synthesis exerted only a trivial effect. VG expansion was consistently reduced by angiotensin II, but this effect was small (3.8%, P < 0.001). After subtotal nephrectomy, compliance increased by 59% in the remnant glomeruli (P < 0.001); 22% of this increase was attributable to structural changes, and the remainder was attributable to the large basal VG of the hypertrophied glomeruli. Thus the major determinants of VG expansion include capillary wall tension, basal VG, and intrinsic distensibility, which is markedly influenced by the character of the extracellular matrix and only slightly altered by an angiotensin II-modified mesangial cell tone.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Renal Physiol.Home page
T. Yamamoto, Y. Tomura, H. Tanaka, and F. Kajiya
In vivo visualization of characteristics of renal microcirculation in hypertensive and diabetic rats
Am J Physiol Renal Physiol, September 1, 2001; 281(3): F571 - F577.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
J. R. HENEGAR, S. A. BIGLER, L. K. HENEGAR, S. C. TYAGI, and J. E. HALL
Functional and Structural Changes in the Kidney in the Early Stages of Obesity
J. Am. Soc. Nephrol., June 1, 2001; 12(6): 1211 - 1217.
[Abstract] [Full Text]

Home page
 DiabetesHome page
I. Suzuma, Y. Hata, A. Clermont, F. Pokras, S. L. Rook, K. Suzuma, E. P. Feener, and L. P. Aiello
Cyclic Stretch and Hypertension Induce Retinal Expression of Vascular Endothelial Growth Factor and Vascular Endothelial Growth Factor Receptor--2: Potential Mechanisms for Exacerbation of Diabetic Retinopathy by Hypertension
Diabetes, February 1, 2001; 50(2): 444 - 454.
[Abstract] [Full Text]

Home page
 HypertensionHome page
P. R. Mertens, V. Espenkott, B. Venjakob, B. Heintz, S. Handt, and H.-G. Sieberth
Pressure Oscillation Regulates Human Mesangial Cell Growth and Collagen Synthesis
Hypertension, November 1, 1998; 32(5): 945 - 952.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online