| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
AJP - Renal Physiology, Vol 271, Issue 1 143-F149, Copyright © 1996 by American Physiological Society
ARTICLES |
T. Wang and G. Giebisch
Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA.
We have demonstrated in previous studies that luminal administration of low doses of angiotensin II (ANG II) stimulate and high doses of ANG II inhibit fluid and HCO3- transport in proximal tubules of rat kidney. However, the role of ANG II on Na+ and HCO3- transport in the distal nephron has not yet been fully elucidated. The superficial early and late distal tubules (DT) of the nephron segments correspond to the distal convoluted tubule and initial collecting tubule. Accordingly, we investigated the effects of ANG II on Na+, HCO3-, and K+ transport in the early and late DT by separate perfusion of these tubule segments in vivo. [3H]inulin, Na+, K+, and total CO2 concentrations were measured in the perfusate and collected fluid, and transport of sodium (JNa), bicarbonate (JHCO3), potassium (JK), and fluid (JV) were analyzed as an index of the hormone effect. Intravenous infusion of the ANG II receptor antagonist [Sar1,Ile8]ANG II (1 microgram.kg-1.min-1) decreased JV, JNa, and JHCO3 in the early DT and decreased Jv and JNa in the late DT. Addition of ANG II (10(-11) M) to the tubular perfusate significantly increased the Jv, JNa, and JHCO3 in the early DT. Similar studies in late DT demonstrated an increase in Jv and JNa, decrease in JK, but no effect on JHCO3. The effects of ANG II on fluid and ion transport were abolished by the luminal application of amiloride (10(-3) M) and of the angiotensin-receptor blocker [Sar1,Ile8]ANG II (10(-6) M). These results suggest that ANG II stimulates Na+/H+ exchange in the early DT (distal convoluted tubule) and amiloride-sensitive Na+ transport (Na+ channels) in the late DT (initial collecting tubule) of cortical nephrons.
This article has been cited by other articles:
|
|
 |
|
  M. Hatch and R. W. Freel Increased colonic sodium absorption in rats with chronic renal failure is partially mediated by AT1 receptor agonism Am J Physiol Gastrointest Liver Physiol, August 1, 2008; 295(2): G348 - G356. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. K. Madala Halagappa, S. Tiwari, S. Riazi, X. Hu, and C. M. Ecelbarger Chronic candesartan alters expression and activity of NKCC2, NCC, and ENaC in the obese Zucker rat Am J Physiol Renal Physiol, May 1, 2008; 294(5): F1222 - F1231. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. E. Yang, P. K. K. Leong, and A. A. McDonough Reducing blood pressure in SHR with enalapril provokes redistribution of NHE3, NaPi2, and NCC and decreases NaPi2 and ACE abundance Am J Physiol Renal Physiol, October 1, 2007; 293(4): F1197 - F1208. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. B. Sandberg, A. D. M. Riquier, K. Pihakaski-Maunsbach, A. A. McDonough, and A. B. Maunsbach ANG II provokes acute trafficking of distal tubule Na+-Cl cotransporter to apical membrane Am J Physiol Renal Physiol, September 1, 2007; 293(3): F662 - F669. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. W. Verlander The thiazide-sensitive NaCl cotransporter: a new target for acute regulation of salt and water transport by angiotensin II Am J Physiol Renal Physiol, September 1, 2007; 293(3): F660 - F661. [Full Text] [PDF]
|
|
|
|
|
|
Y. Ozawa and H. Kobori Crucial role of Rho-nuclear factor-{kappa}B axis in angiotensin II-induced renal injury Am J Physiol Renal Physiol, July 1, 2007; 293(1): F100 - F109. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Sun, D.-H. Lin, T. Wang, E. Babilonia, Z. Wang, Y. Jin, R. Kemp, A. Nasjletti, and W.-H. Wang Low Na intake suppresses expression of CYP2C23 and arachidonic acid-induced inhibition of ENaC Am J Physiol Renal Physiol, December 1, 2006; 291(6): F1192 - F1200. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. W. Good, T. George, and B. A. Watts III Nongenomic regulation by aldosterone of the epithelial NHE3 Na+/H+ exchanger Am J Physiol Cell Physiol, March 1, 2006; 290(3): C757 - C763. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Weinstein A mathematical model of rat distal convoluted tubule. I. Cotransporter function in early DCT Am J Physiol Renal Physiol, October 1, 2005; 289(4): F699 - F720. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Weinstein A mathematical model of rat distal convoluted tubule. II. Potassium secretion along the connecting segment Am J Physiol Renal Physiol, October 1, 2005; 289(4): F721 - F741. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Loghman-Adham, C. E. Soto, T. Inagami, and C. Sotelo-Avila Expression of Components of the Renin-angiotensin System in Autosomal Recessive Polycystic Kidney Disease J. Histochem. Cytochem., August 1, 2005; 53(8): 979 - 988. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. A. Wagner, K. E. Finberg, S. Breton, V. Marshansky, D. Brown, and J. P. Geibel Renal Vacuolar H+-ATPase Physiol Rev, October 1, 2004; 84(4): 1263 - 1314. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Loghman-Adham, C. E. Soto, T. Inagami, and L. Cassis The intrarenal renin-angiotensin system in autosomal dominant polycystic kidney disease Am J Physiol Renal Physiol, October 1, 2004; 287(4): F775 - F788. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Lerolle, S. Bourgeois, F. Leviel, G. Lebrun, M. Paillard, and P. Houillier Angiotensin II inhibits NaCl absorption in the rat medullary thick ascending limb Am J Physiol Renal Physiol, September 1, 2004; 287(3): F404 - F410. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. H. Le, M. I. Oliverio, H.-S. Kim, H. Salzler, R. C. Dash, D. N. Howell, O. Smithies, S. Bronson, and T. M. Coffman A {gamma}GT-AT1A receptor transgene protects renal cortical structure in AT1 receptor-deficient mice Physiol Genomics, August 11, 2004; 18(3): 290 - 298. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. M. Vehaskari, T. Stewart, D. Lafont, C. Soyez, D. Seth, and J. Manning Kidney angiotensin and angiotensin receptor expression in prenatally programmed hypertension Am J Physiol Renal Physiol, August 1, 2004; 287(2): F262 - F267. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Wei, Y.-J. Chen, D. Li, R. Gu, and W.-H. Wang Dual effect of insulin-like growth factor on the apical 70-pS K channel in the thick ascending limb of rat kidney Am J Physiol Cell Physiol, June 1, 2004; 286(6): C1258 - C1263. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. Wall, M. P. Fischer, D. M. Glapion, and M. De La Calzada ANG II reduces net acid secretion in rat outer medullary collecting duct Am J Physiol Renal Physiol, November 1, 2003; 285(5): F930 - F937. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T.-H. Kwon, J. Nielsen, Y.-H. Kim, M. A. Knepper, J. Frokiaer, and S. Nielsen Regulation of sodium transporters in the thick ascending limb of rat kidney: response to angiotensin II Am J Physiol Renal Physiol, July 1, 2003; 285(1): F152 - F165. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Loffing and B. Kaissling Sodium and calcium transport pathways along the mammalian distal nephron: from rabbit to human Am J Physiol Renal Physiol, April 1, 2003; 284(4): F628 - F643. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Wei and W. Wang Angiotensin II stimulates basolateral K channels in rat cortical collecting ducts Am J Physiol Renal Physiol, January 1, 2003; 284(1): F175 - F181. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. W. Good, T. George, and B. A. Watts III Aldosterone inhibits HCO-3 absorption via a nongenomic pathway in medullary thick ascending limb Am J Physiol Renal Physiol, October 1, 2002; 283(4): F699 - F706. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Frindt, T. McNair, A. Dahlmann, E. Jacobs-Palmer, and L. G. Palmer Epithelial Na channels and short-term renal response to salt deprivation Am J Physiol Renal Physiol, October 1, 2002; 283(4): F717 - F726. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Schou, A. Gabrielsen, N. E. Bruun, P. Skott, B. Pump, H. Dige-Petersen, E. Frandsen, P. Bie, J. Warberg, N. J. Christensen, et al. Angiotensin II attenuates the natriuresis of water immersion in humans Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2002; 283(1): R187 - R196. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Peti-Peterdi, D. G. Warnock, and P. D. Bell Angiotensin II Directly Stimulates ENaC Activity in the Cortical Collecting Duct via AT1 Receptors J. Am. Soc. Nephrol., May 1, 2002; 13(5): 1131 - 1135. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. G. Navar, L. M. Harrison-Bernard, A. Nishiyama, and H. Kobori Regulation of Intrarenal Angiotensin II in Hypertension Hypertension, February 1, 2002; 39(2): 316 - 322. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Charbonneau, M. Leclerc, and M. G. Brunette Effect of angiotensin II on calcium reabsorption by the luminal membranes of the nephron Am J Physiol Endocrinol Metab, June 1, 2001; 280(6): E928 - E936. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-M. LALOUEL, A. ROHRWASSER, D. TERREROS, T. MORGAN, and K. WARD Angiotensinogen in Essential Hypertension: From Genetics to Nephrology J. Am. Soc. Nephrol., March 1, 2001; 12(3): 606 - 615. [Abstract] [Full Text]
|
|
|
|
 |
|
 L G. Navar, K. D Mitchell, L. M Harrison-Bernard, H. Kobori, and A. Nishiyama Review: Intrarenal angiotensin II levels in normal and hypertensive states Journal of Renin-Angiotensin-Aldosterone System, March 1, 2001; 2(1_suppl): S176 - S184. [PDF]
|
|
|
|
|
|
A. Kato, J. D. Klein, C. Zhang, and J. M. Sands Angiotensin II increases vasopressin-stimulated facilitated urea permeability in rat terminal IMCDs Am J Physiol Renal Physiol, November 1, 2000; 279(5): F835 - F840. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-T. Wang, S. Y. Chin, and L. G. Navar Impairment of pressure-natriuresis and renal autoregulation in ANG II-infused hypertensive rats Am J Physiol Renal Physiol, August 1, 2000; 279(2): F319 - F325. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Z. Levine, M. Iacovitti, B. Luck, M. T. Hincke, K. D. Burns, and J. N. Fryer Surviving rat distal tubule bicarbonate reabsorption: effects of chronic AT1 blockade Am J Physiol Renal Physiol, March 1, 2000; 278(3): F476 - F483. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. I. Oliverio, C. F. Best, O. Smithies, and T. M. Coffman Regulation of Sodium Balance and Blood Pressure by the AT1A Receptor for Angiotensin II Hypertension, February 1, 2000; 35(2): 550 - 554. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. F. Reilly and D. H. Ellison Mammalian Distal Tubule: Physiology, Pathophysiology, and Molecular Anatomy Physiol Rev, January 1, 2000; 80(1): 277 - 313. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. C. F. Sandgaard, J. L. Andersen, and P. Bie Hormonal regulation of renal sodium and water excretion during normotensive sodium loading in conscious dogs Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2000; 278(1): R11 - R18. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. I. Oliverio, M. Delnomdedieu, C. F. Best, P. Li, M. Morris, M. F. Callahan, G. A. Johnson, O. Smithies, and T. M. Coffman Abnormal water metabolism in mice lacking the type 1A receptor for ANG II Am J Physiol Renal Physiol, January 1, 2000; 278(1): F75 - F82. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Rohrwasser, T. Morgan, H. F. Dillon, L. Zhao, C. W. Callaway, E. Hillas, S. Zhang, T. Cheng, T. Inagami, K. Ward, et al. Elements of a Paracrine Tubular Renin-Angiotensin System Along the Entire Nephron Hypertension, December 1, 1999; 34(6): 1265 - 1274. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. W. Good, T. George, and D. H. Wang Angiotensin II inhibits HCO-3 absorption via a cytochrome P-450-dependent pathway in MTAL Am J Physiol Renal Physiol, May 1, 1999; 276(5): F726 - F736. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z.-Q. Wang, L. J. Millatt, N. T. Heiderstadt, H. M. Siragy, R. A. Johns, and R. M. Carey Differential Regulation of Renal Angiotensin Subtype AT1A and AT2 Receptor Protein in Rats With Angiotensin-Dependent Hypertension Hypertension, January 1, 1999; 33(1): 96 - 101. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Amlal, C. LeGoff, C. Vernimmen, M. Soleimani, M. Paillard, and M. Bichara ANG II controls Na+-K+(NH+4)-2Cl- cotransport via 20-HETE and PKC in medullary thick ascending limb Am J Physiol Cell Physiol, April 1, 1998; 274(4): C1047 - C1056. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
