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Am J Physiol Renal Physiol 271: F489-F497, 1996;
0363-6127/96 $5.00
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AJP - Renal Physiology, Vol 271, Issue 3 489-F497, Copyright © 1996 by American Physiological Society

ARTICLES

Urodilatin is involved in sodium homeostasis and exerts sodium-state-dependent natriuretic and diuretic effects

M. Meyer, R. Richter, R. Brunkhorst, E. Wrenger, P. Schulz-Knappe, A. Kist, P. Mentz, E. G. Brabant, K. M. Koch, G. Rechkemmer and W. G. Forssmann
Department of Nephrology, Hannover Medical School, Germany.

Urodilatin is involved in sodium homeostasis exerts sodium-state-dependent natriuretic and diuretic cts. Eight male volunteers participated in a study consisting of three consecutive phases of 7 days each. The volunteers a sodium diet with 52, 172.6, and 347.8 mmol um/day. Sodium excretion increased from 57.4 +/- 3.7 via .8 +/- 4.6 (P < 0.001) to 322.5 +/- 10.2 mmol/24 h (P < 0.001) at the end of each sodium diet. Urinary urodilatin excretion increased from 24.8 +/- 3.0 via 35.5 +/- 9.0 (P = 0.07) to 49.0 = mol/min (P < 0.01). At the end of each diet, urodilatin was infused for 2 h at 20 ng.kg body wt-1.min-1. Natriuresis increased after low- (4.1 to 52.9 mmol/h, P < 0.001), normal (6.9 to 44.9 mmol/h, P < 0.05), and high-sodium diet (20.1 to 102.9 mmol/h, P < 0.001). Diuresis increased from 174 to 709 (P < 0.001), 395 to 1,026 (P < 0.05), and 266 to 1,339 ml/h < 0.001). The present results indicate that endogenous urodilatin plays an important role in sodium homeostasis and that renal response to exogenous urodilatin is modulated by sodium balance.


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