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Am J Physiol Renal Physiol 271: F670-F678, 1996;
0363-6127/96 $5.00
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AJP - Renal Physiology, Vol 271, Issue 3 670-F678, Copyright © 1996 by American Physiological Society

ARTICLES

Reduced bicarbonate secretion mediates increased distal tubule acidification induced by dietary acid

D. E. Wesson
Veterans Affairs Medical Center, Houston, Texas, USA.

We examined the components of net HCO3 reabsorption (H+/HCO3 secretion) in in vivo perfused distal tubules of anesthetized rats to determine the mechanisms by which dietary acid increases acidification in this nephron segment. Animals eating a minimum electrolyte diet drank either 80 mM NH4Cl or 40 mM (NH4)2SO4 for 7-10 days and were compared with controls drinking distilled H2O. Net HCO3 reabsorption in distal tubules perfused with HCO3 concentration ([HCO3]) similar to that in situ (5 mM) was higher in (NH4)2SO4 animals than in control (21.6 +/- 1.8 vs. 12.5 +/- 1.3 pmol.mm-1.min-1, respectively, P < 0.02), but that for NH4Cl (17.9 +/- 1.5 pmol.mm-1.min-1, P = 0.09 vs. control) animals was not. Calculated H+ secretion was not different among groups perfused with the 5 mM HCO3 solution, but calculated HCO3 secretion was lower in (NH4)2SO4 animals than control (-2.4 +/- 0.3 vs. -5.3 +/- 0.6 pmol.mm-1.min-1, respectively, P < 0.02), but that for NH4Cl (-7.2 +/- 0.7 pmol.mm-1.min-1, P = not significant vs. control) was not. When distal tubules were perfused with solutions containing higher [HCO3] (10 nM), both net HCO3 reabsorption and calculated H+ secretion were significantly higher than control in both acid-ingesting groups. The data show that reduced HCO3 secretion mediates the increased distal tubule acidification induced by dietary acid, particularly at the low tubule fluid [HCO3] in situ. The data also show that acid ingested as the Cl- compared with the SO4(-) salt does not reduce HCO3 secretion and less effectively increases acidification in this nephron segment.


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 Am. J. Physiol. Renal Physiol.Home page
D. E. Wesson
Dietary acid increases blood and renal cortical acid content in rats
Am J Physiol Renal Physiol, January 1, 1998; 274(1): F97 - F103.
[Abstract] [Full Text] [PDF]


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