AJP - Renal Physiology, Vol 271, Issue 6 1103-F1113, Copyright © 1996 by American Physiological Society

ARTICLES

Growth factors and the kidney: regulation of epithelial cell movement and morphogenesis

L. G. Cantley
Division of Nephrology, Beth Israel Hospital, Boston, Massachusetts 02215, USA.

The control of epithelial cell movement and shape change is complex and requires regulation of a broad range of events including cell-cell adhesion contacts, cell-substratum interactions, and the actin cytoskeleton. Utilizing the hepatocyte growth factor tyrosine kinase receptor, c-met, the present review examines how growth factor receptors activate intracellular signaling pathways, which can then regulate the events necessary for epithelial cells to disassemble their existing structure, undergo extensive shape change and cell body movement, and reassemble into a polarized epithelium. The role of growth factor-mediated activation of the phosphoinositide 3-kinase, phospholipase C-gamma, c-src family members, and ras family members is addressed in relation to integrin-mediated cell-basement membrane contacts, cadherin-mediated cell-cell adhesions, and regulation of the actin cytoskeleton.

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