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Am J Physiol Renal Physiol 271: F1224-F1233, 1996;
0363-6127/96 $5.00
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AJP - Renal Physiology, Vol 271, Issue 6 1224-F1233, Copyright © 1996 by American Physiological Society

ARTICLES

Single-channel properties of swelling-activated anion conductance in rat inner medullary collecting duct cells

S. H. Boese, R. K. Kinne and F. Wehner
Max-Planck-Institut fur Molekulare Physiologie, Abteilung Epithelphysiologie, Dortmund, Germany.

Single-channel properties of the volume-activated outwardly rectifying Cl- conductance of rat IMCD cells were studied in primary cultures by means of the patch-clamp technique in the whole cell and in the outside-out configuration. Measurements were performed by noise analysis and in single-channel recordings during voltage-induced current inactivation and reactivation and in long-lasting experiments at constant membrane voltages. Unitary conductances could be defined for the voltage range of -100 to -50 mV and between +50 and +120 mV and chord conductances of 34.1 and 76.6 pS, respectively, can be calculated. The overall current-to-voltage relationship very much resembles that of the macroscopic Cl- conductance and the open probability of the activated channel is close to unity (Po = 0.98-0.99). The channel exhibits many similarities to volume-activated outwardly rectifying Cl- channels found in other systems although certain species differences do exist.


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