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/OH/HCO3
exchanger in the kidney cortex
1 Department of Medicine, University of Cincinnati and 2 Veterans Affairs Medical Center at Cincinnati, Cincinnati Ohio 45267-0585; and 3 Department of Medicine, Northwestern University, Chicago, Illinois 60611
The identities of the apical
Cl
/base exchangers in kidney proximal tubule and cortical
collecting duct (CCD) cells remain unknown. Pendrin (PDS), which is
expressed at high levels in the thyroid and its mutation causes
Pendred's syndrome, is shown to be an anion exchanger. We investigated
the renal distribution of PDS and its function. Our results demonstrate
that pendrin mRNA expression in the rat kidney is abundant and limited
to the cortex. Proximal tubule suspensions isolated from kidney cortex were highly enriched in pendrin mRNA. Immunoblot analysis studies localized pendrin to cortical brush-border membranes. Nephron segment
RT-PCR localized pendrin mRNA to proximal tubule and CCD. Expression
studies in HEK-293 cells demonstrated that pendrin functions in the
Cl/OH,
Cl/HCO3, and Cl/formate
exchange modes. The conclusion is that pendrin is an apical
Cl/base exchanger in the kidney proximal tubule and CCD
and mediates Cl/OH,
Cl/HCO3, and Cl/formate exchange.
proximal tubule; cortical collecting duct; anion exchanger; apical membrane
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Y.-H. Kim, T.-H. Kwon, S. Frische, J. Kim, C. C. Tisher, K. M. Madsen, and S. Nielsen Immunocytochemical localization of pendrin in intercalated cell subtypes in rat and mouse kidney Am J Physiol Renal Physiol, October 1, 2002; 283(4): F744 - F754. [Abstract] [Full Text] [PDF]
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Q. Xie, R. Welch, A. Mercado, M. F. Romero, and D. B. Mount Molecular characterization of the murine Slc26a6 anion exchanger: functional comparison with Slc26a1 Am J Physiol Renal Physiol, October 1, 2002; 283(4): F826 - F838. [Abstract] [Full Text] [PDF]
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T. Greeley, H. Shumaker, Z. Wang, C. W. Schweinfest, and M. Soleimani Downregulated in adenoma and putative anion transporter are regulated by CFTR in cultured pancreatic duct cells Am J Physiol Gastrointest Liver Physiol, November 1, 2001; 281(5): G1301 - G1308. [Abstract] [Full Text] [PDF]
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 I. E. Royaux, S. M. Wall, L. P. Karniski, L. A. Everett, K. Suzuki, M. A. Knepper, and E. D. Green Pendrin, encoded by the Pendred syndrome gene, resides in the apical region of renal intercalated cells and mediates bicarbonate secretion PNAS, March 27, 2001; 98(7): 4221 - 4226. [Abstract] [Full Text] [PDF]
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Z. Wang, S. Petrovic, E. Mann, and M. Soleimani Identification of an apical Cl-/HCO3- exchanger in the small intestine Am J Physiol Gastrointest Liver Physiol, March 1, 2002; 282(3): G573 - G579. [Abstract] [Full Text] [PDF]
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