| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1 Program in Cell Biology and Biochemistry, The Hospital for Sick Children, and Biochemistry Department, University of Toronto, Toronto, Ontario, Canada, M5G 1X8; and 2 Institut de Pharmacologie, Lausanne, Switzerland CH-1005
The epithelial Na+ channel (ENaC) plays a key role in the regulation of Na+ and water absorption in several epithelia, including those of the distal nephron, distal colon, and lung. Accordingly, mutations in ENaC leading to reduced or increased channel activity cause human diseases such as pseudohypoaldosteronism type I or Liddle's syndrome, respectively. The gain of ENaC function in Liddle's syndrome is associated with increased activity and stability of the channel at the plasma membrane. Thus understanding the regulation of channel processing and trafficking to and stability at the cell surface is of fundamental importance. This review describes some of the recent advances in our understanding of ENaC trafficking, including the role of glycosylation, ENaC solubility in nonionic detergent, targeting signal(s) and hormones. It also describes the regulation of ENaC stability at the cell surface and the roles of the ubiquitin ligase Nedd4 (and ubiquitination) and clathrin-mediated endocytosis in that regulation.
epithelia sodium channel; glycosylation; ubiquitin; Nedd4; endocytosis; WW domain; Liddle's syndrome
This article has been cited by other articles:
|
|
 |
|
  M. B. Butterworth, R. S. Edinger, R. A. Frizzell, and J. P. Johnson Regulation of the epithelial sodium channel by membrane trafficking Am J Physiol Renal Physiol, January 1, 2009; 296(1): F10 - F24. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. H. Yoshimura, S. Iwasaka, W. Schwarz, and K. Takeyasu Fast degradation of the auxiliary subunit of Na+/K+-ATPase in the plasma membrane of HeLa cells J. Cell Sci., July 1, 2008; 121(13): 2159 - 2168. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. M. Weixel, R. S. Edinger, L. Kester, C. J. Guerriero, H. Wang, L. Fang, T. R. Kleyman, P. A. Welling, O. A. Weisz, and J. P. Johnson Phosphatidylinositol 4-Phosphate 5-Kinase Reduces Cell Surface Expression of the Epithelial Sodium Channel (ENaC) in Cultured Collecting Duct Cells J. Biol. Chem., December 14, 2007; 282(50): 36534 - 36542. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Mukhopadhyay and H. Riezman Proteasome-Independent Functions of Ubiquitin in Endocytosis and Signaling Science, January 12, 2007; 315(5809): 201 - 205. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. G. Folkesson and M. A. Matthay Alveolar Epithelial Ion and Fluid Transport: Recent Progress Am. J. Respir. Cell Mol. Biol., July 1, 2006; 35(1): 10 - 19. [Full Text] [PDF]
|
|
|
|
|
|
O. Pochynyuk, Q. Tong, A. Staruschenko, H.-P. Ma, and J. D. Stockand Regulation of the epithelial Na+ channel (ENaC) by phosphatidylinositides Am J Physiol Renal Physiol, May 1, 2006; 290(5): F949 - F957. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Otulakowski, B. Rafii, M. Harris, and H. O'Brodovich Oxygen and Glucocorticoids Modulate {alpha}ENaC mRNA Translation in Fetal Distal Lung Epithelium Am. J. Respir. Cell Mol. Biol., February 1, 2006; 34(2): 204 - 212. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Joe, N. E. Letwin, M. R. Garrett, S. Dhindaw, B. Frank, R. Sultana, K. Verratti, J. P. Rapp, and N. H. Lee Transcriptional profiling with a blood pressure QTL interval-specific oligonucleotide array Physiol Genomics, November 17, 2005; 23(3): 318 - 326. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. R. Conti and C. A. Vandenberg ERADication of ion channels destined for the plasma membrane. Focus on "Role of ubiquitin-proteasome degradation pathway in biogenesis efficiency of {beta}-cell ATP-sensitive potassium channels" Am J Physiol Cell Physiol, November 1, 2005; 289(5): C1072 - C1074. [Full Text] [PDF]
|
|
|
|
|
|
M. Moody, C. Pennington, C. Schultz, R. Caldwell, C. Dinkel, M. W. Rossi, S. McNamara, J. Widdicombe, S. Gabriel, and A. E. Traynor-Kaplan Inositol polyphosphate derivative inhibits Na+ transport and improves fluid dynamics in cystic fibrosis airway epithelia Am J Physiol Cell Physiol, September 1, 2005; 289(3): C512 - C520. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Bachmann, K. Mutig, J. Bates, P. Welker, B. Geist, V. Gross, F. C. Luft, N. Alenina, M. Bader, B. J. Thiele, et al. Renal effects of Tamm-Horsfall protein (uromodulin) deficiency in mice Am J Physiol Renal Physiol, March 1, 2005; 288(3): F559 - F567. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. W. Jackman and S. C. Kandarian The molecular basis of skeletal muscle atrophy Am J Physiol Cell Physiol, October 1, 2004; 287(4): C834 - C843. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Xie and J. A. Schafer Inhibition of ENaC by intracellular Cl- in an MDCK clone with high ENaC expression Am J Physiol Renal Physiol, October 1, 2004; 287(4): F722 - F731. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Mies, V. Shlyonsky, A. Goolaerts, and S. Sariban-Sohraby Modulation of epithelial Na+ channel activity by long-chain n-3 fatty acids Am J Physiol Renal Physiol, October 1, 2004; 287(4): F850 - F855. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Nesti, B. Everill, and A. D. Morielli Endocytosis as a Mechanism for Tyrosine Kinase-dependent Suppression of a Voltage-gated Potassium Channel Mol. Biol. Cell, September 1, 2004; 15(9): 4073 - 4088. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-L. Ji and D. J. Benos Degenerin Sites Mediate Proton Activation of {delta}{beta}{gamma}-Epithelial Sodium Channel J. Biol. Chem., June 25, 2004; 279(26): 26939 - 26947. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Otulakowski, B. Rafii, and H. O'Brodovich Differential Translational Efficiency of ENaC Subunits During Lung Development Am. J. Respir. Cell Mol. Biol., June 1, 2004; 30(6): 862 - 870. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. A. Weisz and J. P. Johnson Noncoordinate regulation of ENaC: paradigm lost? Am J Physiol Renal Physiol, November 1, 2003; 285(5): F833 - F842. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. A. Itani, J. R. Campbell, J. Herrero, P. M. Snyder, and C. P. Thomas Alternate promoters and variable splicing lead to hNedd4-2 isoforms with a C2 domain and varying number of WW domains Am J Physiol Renal Physiol, November 1, 2003; 285(5): F916 - F929. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. B. Bruns, B. Hu, Y. J. Ahn, S. Sheng, R. P. Hughey, and T. R. Kleyman Multiple epithelial Na+ channel domains participate in subunit assembly Am J Physiol Renal Physiol, October 1, 2003; 285(4): F600 - F609. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Auberson, N. Hoffmann-Pochon, A. Vandewalle, S. Kellenberger, and L. Schild Epithelial Na+ channel mutants causing Liddle's syndrome retain ability to respond to aldosterone and vasopressin Am J Physiol Renal Physiol, September 1, 2003; 285(3): F459 - F471. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Lebowitz, B. An, R. S. Edinger, M. L. Zeidel, and J. P. Johnson Effect of altered Na+ entry on expression of apical and basolateral transport proteins in A6 epithelia Am J Physiol Renal Physiol, September 1, 2003; 285(3): F524 - F531. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. E. Booth and J. D. Stockand Targeted degradation of ENaC in response to PKC activation of the ERK1/2 cascade Am J Physiol Renal Physiol, May 1, 2003; 284(5): F938 - F947. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Rauz, E. A. Walker, S. V. Hughes, M. Coca-Prados, M. Hewison, P. I. Murray, and P. M. Stewart Serum- and Glucocorticoid-Regulated Kinase Isoform-1 and Epithelial Sodium Channel Subunits in Human Ocular Ciliary Epithelium Invest. Ophthalmol. Vis. Sci., April 1, 2003; 44(4): 1643 - 1651. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. C. Carpenter, S. Schomberg, C. Nichols, K. R. Stenmark, and J. V. Weil Hypoxia reversibly inhibits epithelial sodium transport but does not inhibit lung ENaC or Na-K-ATPase expression Am J Physiol Lung Cell Mol Physiol, January 1, 2003; 284(1): L77 - L83. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Becchetti, B. Malik, G. Yue, P. Duchatelle, O. Al-Khalili, T. R. Kleyman, and D. C. Eaton Phosphatase inhibitors increase the open probability of ENaC in A6 cells Am J Physiol Renal Physiol, November 1, 2002; 283(5): F1030 - F1045. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Chraibi and J.-D. Horisberger Na Self Inhibition of Human Epithelial Na Channel: Temperature Dependence and Effect of Extracellular Proteases J. Gen. Physiol., July 30, 2002; 120(2): 133 - 145. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Matthay, H. G. Folkesson, and C. Clerici Lung Epithelial Fluid Transport and the Resolution of Pulmonary Edema Physiol Rev, July 1, 2002; 82(3): 569 - 600. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Matthay Editorial: Alveolar Epithelial Ion and Fluid Transport: Regulation of ion and fluid transport across the distal pulmonary epithelia: new insights Am J Physiol Lung Cell Mol Physiol, April 1, 2002; 282(4): L595 - L598. [Full Text] [PDF]
|
|
|
|
|
|
J. D. Stockand New ideas about aldosterone signaling in epithelia Am J Physiol Renal Physiol, April 1, 2002; 282(4): F559 - F576. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. E. Booth, J. P. Johnson, and J. D. Stockand ALDOSTERONE Advan Physiol Educ, March 1, 2002; 26(1): 8 - 20. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Mery, B. Strauss, J. F. Dufour, K. H. Krause, and M. Hoth The PDZ-interacting domain of TRPC4 controls its localization and surface expression in HEK293 cells J. Cell Sci., January 9, 2002; 115(17): 3497 - 3508. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Hanwell, T. Ishikawa, R. Saleki, and D. Rotin Trafficking and Cell Surface Stability of the Epithelial Na+ Channel Expressed in Epithelial Madin-Darby Canine Kidney Cells J. Biol. Chem., March 15, 2002; 277(12): 9772 - 9779. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
