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Am J Physiol Renal Physiol 283: F810-F816, 2002. First published May 29, 2002; doi:10.1152/ajprenal.00078.2002
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Vol. 283, Issue 4, F810-F816, October 2002

Coordination of the cell cycle is an important determinant of the syndrome of acute renal failure

Judit Megyesi, Lucia Andrade, Jose M. Vieira Jr., Robert L. Safirstein, and Peter M. Price

Department of Internal Medicine, University of Arkansas for Medical Sciences, and Department of Veterans Affairs Medical Center, Little Rock, Arkansas 72205

Recovery from injury is usually accompanied by cell replication, in which new cells replace those irreparably damaged. After acute renal failure, normally quiescent kidney cells enter the cell cycle, which in tubule segments is accompanied by the induction of cell cycle inhibitors. We found that after acute renal failure induced by either cisplatin injection or renal ischemia, induction of the p21 cyclin-dependent kinase (cdk) inhibitor is protective. Mice lacking this gene developed more widespread kidney cell death, more severe renal failure, and had reduced survival, compared with mice with a functional p21 gene. Here, we show induction of 14-3-3sigma , a regulator of G2-to-M transition, after acute renal failure. Our findings, using both in vivo and in vitro models of acute renal failure, show that this protein likely helps to coordinate cell cycle activity to maximize recovery of renal epithelial cells from injury and reduce the extent of the injury itself. Because in terminally differentiated cells, these proteins are highly expressed only after injury, we propose that cell cycle coordination by induction of these proteins could be a general model of tissue recovery from stress and injury.

kidney failure; acute; p21 cyclin kinase inhibitor; cisplatin; ischemia


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