HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (5) Citing Articles via Google Scholar Google Scholar Articles by Ng, C. W. Articles by Badoer, E. Search for Related Content PubMed PubMed Citation Articles by Ng, C. W. Articles by Badoer, E.

Effect of muscimol and L-NAME in the PVN on the RSNA response to volume expansion in conscious rabbits

School of Medical Sciences, Royal Melbourne Institute of Technology University, Bundoora 3083, Melbourne, Victoria, Australia

Submitted 8 December 2003 ; accepted in final form 1 June 2004

In the present study, we have investigated whether the hypothalamic paraventricular nucleus (PVN) contributed to the reflex reduction in renal sympathetic nerve activity (RSNA) normally elicited by volume expansion in the conscious rabbit. RSNA was monitored after volume expansion (Dextran 70, 2 ml/min for 30 min) in animals microinjected into, and outside, the PVN with muscimol (10 nmol), to acutely inhibit neuronal function. Because nitric oxide within the PVN inhibits RSNA, we also examined the effect of N^G-nitro-L-arginine methyl ester (L-NAME; 20 nmol) to block nitric oxide synthase. Compared with vehicle, the reduction in RSNA elicited by volume expansion was abolished by injection of muscimol into the PVN. The effect was specific to the PVN because microinjections of muscimol outside the PVN had no effect on the response. L-NAME microinjected into or outside the PVN had no effect on the RSNA response. The findings suggest that the PVN is essential in the central pathways mediating the renal sympathetic nerve response elicited by elevations in plasma volume but that nitric oxide does not play a major role.

renal nerve activity; conscious rabbit; central reflex regulation

This article has been cited by other articles:

				J. L. Cham and E. Badoer Hypothalamic paraventricular nucleus is critical for renal vasoconstriction elicited by elevations in body temperature Am J Physiol Renal Physiol, February 1, 2008; 294(2): F309 - F315. [Abstract] [Full Text] [PDF]

				A. Kantzides and E. Badoer Activation of NADPH-diaphorase-positive projections to the rostral ventrolateral medulla following cardiac mechanoreceptor stimulation in the conscious rat Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2006; 290(6): R1626 - R1638. [Abstract] [Full Text] [PDF]

				R. Ramchandra, C. J. Barrett, S.-J. Guild, and S. C. Malpas Evidence of differential control of renal and lumbar sympathetic nerve activity in conscious rabbits Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2006; 290(3): R701 - R708. [Abstract] [Full Text] [PDF]