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Am J Physiol Renal Physiol 269: F663-F672, 1995;
0363-6127/95 $5.00
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AJP - Renal Physiology, Vol 269, Issue 5 663-F672, Copyright © 1995 by American Physiological Society

ARTICLES

Aquaporin-3 water channel localization and regulation in rat kidney

C. A. Ecelbarger, J. Terris, G. Frindt, M. Echevarria, D. Marples, S. Nielsen and M. A. Knepper
Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.

The aquaporins are a family of water channels expressed in several water-transporting tissues, including the kidney. We have used a peptide-derived, affinity-purified polyclonal antibody to aquaporin-3 (AQP-3) to investigate its localization and regulation in the kidney. Immunoblotting experiments showed expression in both renal cortex and medulla, with greatest expression in the base of the inner medulla. Subcellular fractionation of membranes, using progressively higher centrifugation speeds, revealed that AQP-3 is present predominantly in the 4,000 and 17,000 g pellets and, in contrast to AQP-2, is virtually absent in the high-speed (200,000 g) pellet that contains small intracellular vesicles. Immunocytochemistry and immunofluorescence studies revealed that labeling is restricted to the cortical, outer medullary, and inner medullary collecting ducts. Within the collecting duct, principal cells were labeled, whereas intercalated cells were unlabeled. Consistent with previous immunofluorescence studies (K. Ishibashi, S. Sasaki, K. Fushimi, S. Uchida, M. Kuwahara, H. Saito, T. Furukawa, K. Nakajima, Y. Yamaguchi, T. Gojobori, and F. Marumo. Proc. Natl. Acad. Sci. USA 91: 6269-6273, 1994; T. Ma, A. Frigeri, H. Hasegawa, and A. S. Verkman. J. Biol. Chem. 269: 21845-21849, 1994), the labeling was confined to the basolateral domain. Immunoelectron microscopy, using the immunogold technique in ultrathin cryosections, demonstrated a predominant labeling of the basolateral plasma membranes. In contrast to previous findings with AQP-2, there was only limited AQP-3 labeling of intracellular vesicles, suggesting that this water channel is not regulated acutely through vesicular trafficking. Immunoblotting studies revealed that thirsting of rats for 48 h approximately doubled the amount of AQP-3 protein in the inner medulla. These studies are consistent with a role for AQP-3 in osmotically driven water absorption across the collecting duct epithelium and suggest that the expression of AQP-3 is regulated on a long-term basis.


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L. N. Nejsum, T.-H. Kwon, D. Marples, A. Flyvbjerg, M. A. Knepper, J. Frokiar, and S. Nielsen
Compensatory increase in AQP2, p-AQP2, and AQP3 expression in rats with diabetes mellitus
Am J Physiol Renal Physiol, April 1, 2001; 280(4): F715 - F726.
[Abstract] [Full Text] [PDF]

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 Am. J. Respir. Cell Mol. Bio.Home page
S. M. Kreda, M. C. Gynn, D. A. Fenstermacher, R. C. Boucher, and S. E. Gabriel
Expression and Localization of Epithelial Aquaporins in the Adult Human Lung
Am. J. Respir. Cell Mol. Biol., March 1, 2001; 24(3): 224 - 234.
[Abstract] [Full Text] [PDF]

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 Am. J. Physiol. Renal Physiol.Home page
C. Shayakul, H. Tsukaguchi, U. V. Berger, and M. A. Hediger
Molecular characterization of a novel urea transporter from kidney inner medullary collecting ducts
Am J Physiol Renal Physiol, March 1, 2001; 280(3): F487 - F494.
[Abstract] [Full Text] [PDF]

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 Am. J. Physiol. Renal Physiol.Home page
D. Promeneur, T.-H. Kwon, M. Yasui, G.-H. Kim, J. Frokiar, M. A. Knepper, P. Agre, and S. Nielsen
Regulation of AQP6 mRNA and protein expression in rats in response to altered acid-base or water balance
Am J Physiol Renal Physiol, December 1, 2000; 279(6): F1014 - F1026.
[Abstract] [Full Text] [PDF]

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 Am. J. Physiol. Renal Physiol.Home page
R. A. Coleman, D. C. Wu, J. Liu, and J. B. Wade
Expression of aquaporins in the renal connecting tubule
Am J Physiol Renal Physiol, November 1, 2000; 279(5): F874 - F883.
[Abstract] [Full Text] [PDF]

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 J. Am. Soc. Nephrol.Home page
G. VALENTI, A. LAERA, G. PACE, G. ACETO, M. L. LOSPALLUTI, R. PENZA, F. P. SELVAGGI, M. L. CHIOZZA, and M. SVELTO
Urinary Aquaporin 2 and Calciuria Correlate with the Severity of Enuresis in Children
J. Am. Soc. Nephrol., October 1, 2000; 11(10): 1873 - 1881.
[Abstract] [Full Text]

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 Am. J. Physiol. Renal Physiol.Home page
T.-H. Kwon, U. H. Laursen, D. Marples, A. B. Maunsbach, M. A. Knepper, J. Frokiar, and S. Nielsen
Altered expression of renal AQPs and Na+ transporters in rats with Lithium-induced NDI
Am J Physiol Renal Physiol, September 1, 2000; 279(3): F552 - F564.
[Abstract] [Full Text] [PDF]

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 Am. J. Physiol. Renal Physiol.Home page
C. A. Ecelbarger, G.-H. Kim, J. Terris, S. Masilamani, C. Mitchell, I. Reyes, J. G. Verbalis, and M. A. Knepper
Vasopressin-mediated regulation of epithelial sodium channel abundance in rat kidney
Am J Physiol Renal Physiol, July 1, 2000; 279(1): F46 - F53.
[Abstract] [Full Text] [PDF]

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 J. Am. Soc. Nephrol.Home page
P. AGRE
Aquaporin Water Channels in Kidney
J. Am. Soc. Nephrol., April 1, 2000; 11(4): 764 - 777.
[Full Text] [PDF]

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 Am. J. Physiol. Renal Physiol.Home page
L. S. Weinstein, S. Yu, and C. A. Ecelbarger
Variable imprinting of the heterotrimeric G protein Gs alpha -subunit within different segments of the nephron
Am J Physiol Renal Physiol, April 1, 2000; 278(4): F507 - F514.
[Abstract] [Full Text] [PDF]

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 J. Histochem. Cytochem.Home page
T. Matsuzaki, T. Suzuki, H. Koyama, S. Tanaka, and K. Takata
Water Channel Protein AQP3 Is Present in Epithelia Exposed to the Environment of Possible Water Loss
J. Histochem. Cytochem., October 1, 1999; 47(10): 1275 - 1286.
[Abstract] [Full Text]

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 J. Am. Soc. Nephrol.Home page
T. MURASE, C. A. ECELBARGER, E. A. BAKER, Y. TIAN, M. A. KNEPPER, and J. G. VERBALIS
Kidney Aquaporin-2 Expression during Escape from Antidiuresis Is Not Related to Plasma or Tissue Osmolality
J. Am. Soc. Nephrol., October 1, 1999; 10(10): 2067 - 2075.
[Abstract] [Full Text]

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 J. Am. Soc. Nephrol.Home page
P. FERNÁNDEZ-LLAMA, R. TURNER, G. DIBONA, and M. A. KNEPPER
Renal Expression of Aquaporins in Liver Cirrhosis Induced by Chronic Common Bile Duct Ligation in Rats
J. Am. Soc. Nephrol., September 1, 1999; 10(9): 1950 - 1957.
[Abstract] [Full Text]

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 Am. J. Physiol. Renal Physiol.Home page
T.-H. Kwon, J. Frokiaer, P. Fernandez-Llama, M. A. Knepper, and S. Nielsen
Reduced abundance of aquaporins in rats with bilateral ischemia-induced acute renal failure: prevention by alpha -MSH
Am J Physiol Renal Physiol, September 1, 1999; 277(3): F413 - F427.
[Abstract] [Full Text] [PDF]

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 J. Am. Soc. Nephrol.Home page
P. FERNÁNDEZ-LLAMA, P. ANDREWS, R. TURNER, S. SAGGI, J. DIMARI, T.-H. KWON, S. NIELSEN, R. SAFIRSTEIN, and M. A. KNEPPER
Decreased Abundance of Collecting Duct Aquaporins in Post-Ischemic Renal Failure in Rats
J. Am. Soc. Nephrol., August 1, 1999; 10(8): 1658 - 1668.
[Abstract] [Full Text]

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 Am. J. Physiol. Renal Physiol.Home page
P. Fernandez-Llama, C. A. Ecelbarger, J. A. Ware, P. Andrews, A. J. Lee, R. Turner, S. Nielsen, and M. A. Knepper
Cyclooxygenase inhibitors increase Na-K-2Cl cotransporter abundance in thick ascending limb of Henle's loop
Am J Physiol Renal Physiol, August 1, 1999; 277(2): F219 - F226.
[Abstract] [Full Text] [PDF]

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 Am. J. Physiol. Renal Physiol.Home page
C. A. Ecelbarger, S. Yu, A. J. Lee, L. S. Weinstein, and M. A. Knepper
Decreased renal Na-K-2Cl cotransporter abundance in mice with heterozygous disruption of the Gsalpha gene
Am J Physiol Renal Physiol, August 1, 1999; 277(2): F235 - F244.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
T. Zeuthen and D. A. Klaerke
Transport of Water and Glycerol in Aquaporin 3 Is Gated by H+
J. Biol. Chem., July 30, 1999; 274(31): 21631 - 21636.
[Abstract] [Full Text] [PDF]

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 J. Am. Soc. Nephrol.Home page
H. WEN, J. FRØKI&Aelig;R, T.-H. KWON, and S. NIELSEN
Urinary Excretion of Aquaporin-2 in Rat Is Mediated by a Vasopressin-Dependent Apical Pathway
J. Am. Soc. Nephrol., July 1, 1999; 10(7): 1416 - 1429.
[Abstract] [Full Text]

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 Am. J. Physiol. Renal Physiol.Home page
A. Zolotnitskaya and L. M. Satlin
Developmental expression of ROMK in rat kidney
Am J Physiol Renal Physiol, June 1, 1999; 276(6): F825 - F836.
[Abstract] [Full Text] [PDF]

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 Proc. Natl. Acad. Sci. USAHome page
M. Yasui, T.-H. Kwon, M. A. Knepper, S. Nielsen, and P. Agre
Aquaporin-6: An intracellular vesicle water channel protein in renal epithelia
PNAS, May 11, 1999; 96(10): 5808 - 5813.
[Abstract] [Full Text] [PDF]

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 J. Histochem. Cytochem.Home page
D. Tran, N. Stelly, T. Tordjmann, T. Durroux, M. N. Dufour, A. Forchioni, R. Seyer, M. Claret, and G. Guillon
Distribution of Signaling Molecules Involved in Vasopressin-induced Ca2+ Mobilization in Rat Hepatocyte Multiplets
J. Histochem. Cytochem., May 1, 1999; 47(5): 601 - 616.
[Abstract] [Full Text]

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 J. Am. Soc. Nephrol.Home page
M. I. MURILLO-CARRETERO, A. A. ILUNDÁIN, and M. ECHEVARRIA
Regulation of Aquaporin mRNA Expression in Rat Kidney by Water Intake
J. Am. Soc. Nephrol., April 1, 1999; 10(4): 696 - 703.
[Abstract] [Full Text]

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 Am. J. Physiol. Renal Physiol.Home page
T. Inoue, J. Terris, C. A. Ecelbarger, C.-L. Chou, S. Nielsen, and M. A. Knepper
Vasopressin regulates apical targeting of aquaporin-2 but not of UT1 urea transporter in renal collecting duct
Am J Physiol Renal Physiol, April 1, 1999; 276(4): F559 - F566.
[Abstract] [Full Text] [PDF]

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 Am. J. Physiol. Renal Physiol.Home page
I. D. Weiner, A. E. Frank, and C. S. Wingo
Apical proton secretion by the inner stripe of the outer medullary collecting duct
Am J Physiol Renal Physiol, April 1, 1999; 276(4): F606 - F613.
[Abstract] [Full Text] [PDF]

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 Am. J. Physiol. Renal Physiol.Home page
J. Frokiaer, D. Marples, H. Valtin, J. F. Morris, M. A. Knepper, and S. Nielsen
Low aquaporin-2 levels in polyuric DI +/+ severe mice with constitutively high cAMP-phosphodiesterase activity
Am J Physiol Renal Physiol, February 1, 1999; 276(2): F179 - F190.
[Abstract] [Full Text] [PDF]

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 Am. J. Physiol. Renal Physiol.Home page
G.-H. Kim, C. A. Ecelbarger, C. Mitchell, R. K. Packer, J. B. Wade, and M. A. Knepper
Vasopressin increases Na-K-2Cl cotransporter expression in thick ascending limb of Henle's loop
Am J Physiol Renal Physiol, January 1, 1999; 276(1): F96 - F103.
[Abstract] [Full Text] [PDF]

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 Am. J. Physiol. Renal Physiol.Home page
S. Nielsen, A. B. Maunsbach, C. A. Ecelbarger, and M. A. Knepper
Ultrastructural localization of Na-K-2Cl cotransporter in thick ascending limb and macula densa of rat kidney
Am J Physiol Renal Physiol, December 1, 1998; 275(6): F885 - F893.
[Abstract] [Full Text] [PDF]

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 Proc. Natl. Acad. Sci. USAHome page
G.-H. Kim, S. Masilamani, R. Turner, C. Mitchell, J. B. Wade, and M. A. Knepper
The thiazide-sensitive Na-Cl cotransporter is an aldosterone-induced protein
PNAS, November 24, 1998; 95(24): 14552 - 14557.
[Abstract] [Full Text] [PDF]

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 Am. J. Physiol. Renal Physiol.Home page
T.-H. Kwon, J. Frokiaer, M. A. Knepper, and S. Nielsen
Reduced AQP1, -2, and -3 levels in kidneys of rats with CRF induced by surgical reduction in renal mass
Am J Physiol Renal Physiol, November 1, 1998; 275(5): F724 - F741.
[Abstract] [Full Text] [PDF]

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 Am. J. Physiol. Renal Physiol.Home page
T. Inoue, S. Nielsen, B. Mandon, J. Terris, B. K. Kishore, and M. A. Knepper
SNAP-23 in rat kidney: colocalization with aquaporin-2 in collecting duct vesicles
Am J Physiol Renal Physiol, November 1, 1998; 275(5): F752 - F760.
[Abstract] [Full Text] [PDF]

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 Am. J. Physiol. Cell Physiol.Home page
H. Funaki, T. Yamamoto, Y. Koyama, D. Kondo, E. Yaoita, K. Kawasaki, H. Kobayashi, S. Sawaguchi, H. Abe, and I. Kihara
Localization and expression of AQP5 in cornea, serous salivary glands, and pulmonary epithelial cells
Am J Physiol Cell Physiol, October 1, 1998; 275(4): C1151 - C1157.
[Abstract] [Full Text] [PDF]

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 Proc. Natl. Acad. Sci. USAHome page
S. Yu, D. Yu, E. Lee, M. Eckhaus, R. Lee, Z. Corria, D. Accili, H. Westphal, and L. S. Weinstein
Variable and tissue-specific hormone resistance in heterotrimeric Gs protein alpha -subunit (Gsalpha ) knockout mice is due to tissue-specific imprinting of the Gsalpha gene
PNAS, July 21, 1998; 95(15): 8715 - 8720.
[Abstract] [Full Text] [PDF]

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 Am. J. Physiol. Renal Physiol.Home page
B. K. Kishore, J. B. Wade, K. Schorr, T. Inoue, B. Mandon, and M. A. Knepper
Expression of synaptotagmin VIII in rat kidney
Am J Physiol Renal Physiol, July 1, 1998; 275(1): F131 - F142.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
P. Agre, M. Bonhivers, and M. J. Borgnia
The Aquaporins, Blueprints for Cellular Plumbing Systems
J. Biol. Chem., June 12, 1998; 273(24): 14659 - 14662.
[Full Text] [PDF]

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 Am. J. Physiol. Renal Physiol.Home page
C. A. Ecelbarger, C.-L. Chou, A. J. Lee, S. R. DiGiovanni, J. G. Verbalis, and M. A. Knepper
Escape from vasopressin-induced antidiuresis: role of vasopressin resistance of the collecting duct
Am J Physiol Renal Physiol, June 1, 1998; 274(6): F1161 - F1166.
[Abstract] [Full Text] [PDF]

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 Am. J. Physiol. Cell Physiol.Home page
S. Hamann, T. Zeuthen, M. L. Cour, E. A. Nagelhus, O. P. Ottersen, P. Agre, and S. Nielsen
Aquaporins in complex tissues: distribution of aquaporins 1-5 in human and rat eye
Am J Physiol Cell Physiol, May 1, 1998; 274(5): C1332 - C1345.
[Abstract] [Full Text] [PDF]

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 Am. J. Physiol. Renal Physiol.Home page
F. Park, G. Koike, and A. W. Cowley Jr.
Regional time-dependent changes in vasopressin V2 receptor expression in the rat kidney during water restriction
Am J Physiol Renal Physiol, May 1, 1998; 274(5): F906 - F913.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
N. Roudier, J.-M. Verbavatz, C. Maurel, P. Ripoche, and F. Tacnet
Evidence for the Presence of Aquaporin-3 in Human Red Blood Cells
J. Biol. Chem., April 3, 1998; 273(14): 8407 - 8412.
[Abstract] [Full Text] [PDF]

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 J. Neurosci.Home page
E. A. Nagelhus, M. L. Veruki, R. Torp, F.-M. Haug, J. H. Laake, S. Nielsen, P. Agre, and O. P. Ottersen
Aquaporin-4 Water Channel Protein in the Rat Retina and Optic Nerve: Polarized Expression in Muller Cells and Fibrous Astrocytes
J. Neurosci., April 1, 1998; 18(7): 2506 - 2519.
[Abstract] [Full Text] [PDF]

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 Am. J. Physiol. Renal Physiol.Home page
R. Rivers, A. Blanchard, D. Eladari, F. Leviel, M. Paillard, R.-A. Podevin, and M. L. Zeidel
Water and solute permeabilities of medullary thick ascending limb apical and basolateral membranes
Am J Physiol Renal Physiol, March 1, 1998; 274(3): F453 - F462.
[Abstract] [Full Text] [PDF]

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 Am. J. Physiol. Renal Physiol.Home page
G. Frindt, H. Zhou, H. Sackin, and L. G. Palmer
Dissociation of K channel density and ROMK mRNA in rat cortical collecting tubule during K adaptation
Am J Physiol Renal Physiol, March 1, 1998; 274(3): F525 - F531.
[Abstract] [Full Text] [PDF]


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