EDITORIAL FOCUS:

Gerardo Gamba

TRPV4: a new target for the hypertension-related kinases WNK1 and WNK4
Am J Physiol Renal Physiol 290: F1303-F1304, 2006. First published February 7, 2006; doi:10.1152/ajprenal.00030.2006 [Full Text] [PDF]  

Yi Fu, Arohan Subramanya, David Rozansky, and David M. Cohen

WNK kinases influence TRPV4 channel function and localization
Am J Physiol Renal Physiol 290: F1305-F1314, 2006. First published January 10, 2006; doi:10.1152/ajprenal.00391.2005 [Abstract] [Full Text] [PDF]  

INVITED REVIEWS:

Marcela Herrera, Pablo A. Ortiz, and Jeffrey L. Garvin

Regulation of thick ascending limb transport: role of nitric oxide
Am J Physiol Renal Physiol 290: F1279-F1284, 2006; doi:10.1152/ajprenal.00465.2005 [Abstract] [Full Text] [PDF]  

B. Malik, S. R. Price, W. E. Mitch, Q. Yue, and D. C. Eaton

Regulation of epithelial sodium channels by the ubiquitin-proteasome proteolytic pathway
Am J Physiol Renal Physiol 290: F1285-F1294, 2006; doi:10.1152/ajprenal.00432.2005 [Abstract] [Full Text] [PDF]  

Stan F. J. van de Graaf, Joost G. J. Hoenderop, and René J. M. Bindels

Regulation of TRPV5 and TRPV6 by associated proteins
Am J Physiol Renal Physiol 290: F1295-F1302, 2006; doi:10.1152/ajprenal.00443.2005 [Abstract] [Full Text] [PDF]  

ARTICLES:

Brian J. Siroky, William B. Ferguson, Amanda L. Fuson, Yi Xie, Attila Fintha, Peter Komlosi, Bradley K. Yoder, Erik M. Schwiebert, Lisa M. Guay-Woodford, and P. Darwin Bell

Loss of primary cilia results in deregulated and unabated apical calcium entry in ARPKD collecting duct cells
Am J Physiol Renal Physiol 290: F1320-F1328, 2006. First published January 5, 2006; doi:10.1152/ajprenal.00463.2005 [Abstract] [Full Text] [PDF]  

Andrea Hartner, Liliana Schaefer, Markus Porst, Nada Cordasic, Anke Gabriel, Bernd Klanke, Dieter P. Reinhardt, and Karl F. Hilgers

Role of fibrillin-1 in hypertensive and diabetic glomerular disease
Am J Physiol Renal Physiol 290: F1329-F1336, 2006. First published December 27, 2005; doi:10.1152/ajprenal.00284.2005 [Abstract] [Full Text] [PDF] [Supplemental Data]  

G. Sansoè, M. Aragno, R. Mastrocola, J. C. Cutrin, S. Silvano, G. Mengozzi, A. Smedile, F. Rosina, O. Danni, and M. Rizzetto

Overexpression of kidney neutral endopeptidase (EC 3.4.24.11) and renal function in experimental cirrhosis
Am J Physiol Renal Physiol 290: F1337-F1343, 2006. First published January 31, 2006; doi:10.1152/ajprenal.00435.2005 [Abstract] [Full Text] [PDF]  

Peggy Roestenberg, Frans A. van Nieuwenhoven, Jaap A. Joles, Claudia Trischberger, Paula P. Martens, Noelynn Oliver, Jan Aten, Jo W. Höppener, and Roel Goldschmeding

Temporal expression profile and distribution pattern indicate a role of connective tissue growth factor (CTGF/CCN-2) in diabetic nephropathy in mice
Am J Physiol Renal Physiol 290: F1344-F1354, 2006. First published December 27, 2005; doi:10.1152/ajprenal.00174.2005 [Abstract] [Full Text] [PDF]  

Thomas L. Pannabecker and William H. Dantzler

Three-dimensional architecture of inner medullary vasa recta
Am J Physiol Renal Physiol 290: F1355-F1366, 2006. First published December 27, 2005; doi:10.1152/ajprenal.00481.2005 [Abstract] [Full Text] [PDF]  

H. Thomas Lee, Michael Jan, Soo Chan Bae, Jin Deok Joo, Farida R. Goubaeva, Jay Yang, and Mihwa Kim

A₁ adenosine receptor knockout mice are protected against acute radiocontrast nephropathy in vivo
Am J Physiol Renal Physiol 290: F1367-F1375, 2006. First published January 17, 2006; doi:10.1152/ajprenal.00347.2005 [Abstract] [Full Text] [PDF]  

William H. Beierwaltes

cGMP stimulates renin secretion in vivo by inhibiting phosphodiesterase-3
Am J Physiol Renal Physiol 290: F1376-F1381, 2006. First published January 31, 2006; doi:10.1152/ajprenal.00209.2005 [Abstract] [Full Text] [PDF]  

Jia L. Zhuo, Xiao C. Li, Jeffrey L. Garvin, L. Gabriel Navar, and Oscar A. Carretero

Intracellular ANG II induces cytosolic Ca²⁺ mobilization by stimulating intracellular AT₁ receptors in proximal tubule cells
Am J Physiol Renal Physiol 290: F1382-F1390, 2006. First published December 27, 2005; doi:10.1152/ajprenal.00269.2005 [Abstract] [Full Text] [PDF]  

Hui-Fang Cheng, Ming-Zhi Zhang, and Raymond C. Harris

Nitric oxide stimulates cyclooxygenase-2 in cultured cTAL cells through a p38-dependent pathway
Am J Physiol Renal Physiol 290: F1391-F1397, 2006. First published December 27, 2005; doi:10.1152/ajprenal.00315.2005 [Abstract] [Full Text] [PDF]  

Maria V. Suurna, Sharon L. Ashworth, Melanie Hosford, Ruben M. Sandoval, Sarah E. Wean, Bijal M. Shah, James R. Bamburg, and Bruce A. Molitoris

Cofilin mediates ATP depletion-induced endothelial cell actin alterations
Am J Physiol Renal Physiol 290: F1398-F1407, 2006. First published January 24, 2006; doi:10.1152/ajprenal.00194.2005 [Abstract] [Full Text] [PDF]  

Massimo Sabbatini, Mariarosaria Santillo, Antonio Pisani, Roberto Paternò, Francesco Uccello, Rosalba Serù, Gianfranco Matrone, Gianrico Spagnuolo, Michele Andreucci, Vittorio Serio, Pasquale Esposito, Bruno Cianciaruso, Giorgio Fuiano, and Enrico V. Avvedimento

Inhibition of Ras/ERK1/2 signaling protects against postischemic renal injury
Am J Physiol Renal Physiol 290: F1408-F1415, 2006. First published January 24, 2006; doi:10.1152/ajprenal.00304.2005 [Abstract] [Full Text] [PDF]  

Ryan G. Morris, Ewout J. Hoorn, and Mark A. Knepper

Hypokalemia in a mouse model of Gitelman's syndrome
Am J Physiol Renal Physiol 290: F1416-F1420, 2006. First published January 24, 2006; doi:10.1152/ajprenal.00421.2005 [Abstract] [Full Text] [PDF]  

Antoine Nissant, Marc Paulais, Sahran Lachheb, Stéphane Lourdel, and Jacques Teulon

Similar chloride channels in the connecting tubule and cortical collecting duct of the mouse kidney
Am J Physiol Renal Physiol 290: F1421-F1429, 2006. First published January 10, 2006; doi:10.1152/ajprenal.00274.2005 [Abstract] [Full Text] [PDF]  

Amer C. Hakam and Tahir Hussain

Angiotensin II AT₂ receptors inhibit proximal tubular Na⁺-K⁺-ATPase activity via a NO/cGMP-dependent pathway
Am J Physiol Renal Physiol 290: F1430-F1436, 2006. First published December 27, 2005; doi:10.1152/ajprenal.00218.2005 [Abstract] [Full Text] [PDF]  

Gavin S. Stewart, Craig P. Smith, and Gordon J. Cooper

Molecular characterization of the mercurial sensitivity of a frog urea transporter (fUT)
Am J Physiol Renal Physiol 290: F1437-F1442, 2006. First published December 27, 2005; doi:10.1152/ajprenal.00449.2005 [Abstract] [Full Text] [PDF]  

Ramanathan M. Seshadri, Janet D. Klein, Tekla Smith, Jeff M. Sands, Mary E. Handlogten, Jill W. Verlander, and I. David Weiner

Changes in subcellular distribution of the ammonia transporter, Rhcg, in response to chronic metabolic acidosis
Am J Physiol Renal Physiol 290: F1443-F1452, 2006. First published January 24, 2006; doi:10.1152/ajprenal.00459.2005 [Abstract] [Full Text] [PDF]  

Richard A. Zager, Ali C. Johnson, Steve Lund, Sherry Y. Hanson, and Christine K. Abrass

Levosimendan protects against experimental endotoxemic acute renal failure
Am J Physiol Renal Physiol 290: F1453-F1462, 2006. First published January 17, 2006; doi:10.1152/ajprenal.00485.2005 [Abstract] [Full Text] [PDF]  

Richard J. Roman, Kimberly M. Hoagland, Bernardo Lopez, Anne E. Kwitek, Michael R. Garrett, John P. Rapp, Josef Lazar, Howard J. Jacob, and Albert Sarkis

Characterization of blood pressure and renal function in chromosome 5 congenic strains of Dahl S rats
Am J Physiol Renal Physiol 290: F1463-F1471, 2006. First published January 5, 2006; doi:10.1152/ajprenal.00360.2005 [Abstract] [Full Text] [PDF]  

Zhongjie Sun

Genetic AVP deficiency abolishes cold-induced diuresis but does not attenuate cold-induced hypertension
Am J Physiol Renal Physiol 290: F1472-F1477, 2006. First published January 5, 2006; doi:10.1152/ajprenal.00430.2005 [Abstract] [Full Text] [PDF]  

Elena E. Ustinova, Matthew O. Fraser, and Michael A. Pezzone

Colonic irritation in the rat sensitizes urinary bladder afferents to mechanical and chemical stimuli: an afferent origin of pelvic organ cross-sensitization
Am J Physiol Renal Physiol 290: F1478-F1487, 2006. First published January 10, 2006; doi:10.1152/ajprenal.00395.2005 [Abstract] [Full Text] [PDF]  

Shaohu Sheng, Marcelo D. Carattino, James B. Bruns, Rebecca P. Hughey, and Thomas R. Kleyman

Furin cleavage activates the epithelial Na⁺ channel by relieving Na⁺ self-inhibition
Am J Physiol Renal Physiol 290: F1488-F1496, 2006. First published January 31, 2006; doi:10.1152/ajprenal.00439.2005 [Abstract] [Full Text] [PDF]  

Karl D. Pendergrass, David B. Averill, Carlos M. Ferrario, Debra I. Diz, and Mark C. Chappell

Differential expression of nuclear AT₁ receptors and angiotensin II within the kidney of the male congenic mRen2.Lewis rat
Am J Physiol Renal Physiol 290: F1497-F1506, 2006. First published January 10, 2006; doi:10.1152/ajprenal.00317.2005 [Abstract] [Full Text] [PDF]  

Sherry Sours, Juan Du, Shaoyou Chu, Min Ding, Xin J. Zhou, and Rong Ma

Expression of canonical transient receptor potential (TRPC) proteins in human glomerular mesangial cells
Am J Physiol Renal Physiol 290: F1507-F1515, 2006. First published January 17, 2006; doi:10.1152/ajprenal.00268.2005 [Abstract] [Full Text] [PDF]  

Alaa S. Awad, Hong Ye, Liping Huang, Li Li, Frank W. Foss, Jr., Timothy L. Macdonald, Kevin R. Lynch, and Mark D. Okusa

Selective sphingosine 1-phosphate 1 receptor activation reduces ischemia-reperfusion injury in mouse kidney
Am J Physiol Renal Physiol 290: F1516-F1524, 2006. First published January 10, 2006; doi:10.1152/ajprenal.00311.2005 [Abstract] [Full Text] [PDF]  

Marouan Abouhamed, Jakub Gburek, Wei Liu, Blazej Torchalski, Andreas Wilhelm, Natascha A. Wolff, Erik I. Christensen, Frank Thévenod, and Craig P. Smith

Divalent metal transporter 1 in the kidney proximal tubule is expressed in late endosomes/lysosomal membranes: implications for renal handling of protein-metal complexes
Am J Physiol Renal Physiol 290: F1525-F1533, 2006. First published January 31, 2006; doi:10.1152/ajprenal.00359.2005 [Abstract] [Full Text] [PDF]  

Lamine Aoudjit, Anna Potapov, and Tomoko Takano

Prostaglandin E₂ promotes cell survival of glomerular epithelial cells via the EP4 receptor
Am J Physiol Renal Physiol 290: F1534-F1542, 2006. First published January 5, 2006; doi:10.1152/ajprenal.00267.2005 [Abstract] [Full Text] [PDF]  

Patrick K. K. Leong, Li E. Yang, Carol S. Landon, Alicia A. McDonough, and Kay-Pong Yip

Phenol injury-induced hypertension stimulates proximal tubule Na⁺/H⁺ exchanger activity
Am J Physiol Renal Physiol 290: F1543-F1550, 2006. First published January 3, 2006; doi:10.1152/ajprenal.00392.2005 [Abstract] [Full Text] [PDF]  

Andrew K. Gelasco and John R. Raymond

Indoxyl sulfate induces complex redox alterations in mesangial cells
Am J Physiol Renal Physiol 290: F1551-F1558, 2006. First published January 24, 2006; doi:10.1152/ajprenal.00281.2004 [Abstract] [Full Text] [PDF]  

CALL FOR PAPERS:

Peter K. Stricklett, Alisa K. Hughes, and Donald E. Kohan

Endothelin-1 stimulates NO production and inhibits cAMP accumulation in rat inner medullary collecting duct through independent pathways
Am J Physiol Renal Physiol 290: F1315-F1319, 2006. First published December 27, 2005; doi:10.1152/ajprenal.00450.2005 [Abstract] [Full Text] [PDF]  

REPORTS:

Kamyar Zahedi, Monica P. Revelo, Sharon Barone, Zhaohui Wang, Kathy Tehrani, David P. Citron, John J. Bissler, Hamid Rabb, and Manoocher Soleimani

Stathmin-deficient mice develop fibrosis and show delayed recovery from ischemic-reperfusion injury
Am J Physiol Renal Physiol 290: F1559-F1567, 2006. First published January 24, 2006; doi:10.1152/ajprenal.00424.2005 [Abstract] [Full Text] [PDF]  

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