EDITORIAL FOCUS:

Yashpal S. Kanwar and Lin Sun

Shuttling of calcium between endoplasmic reticulum and mitochondria in the renal vasculature
Am J Physiol Renal Physiol 295: F1301-F1302, 2008. First published September 3, 2008; doi:10.1152/ajprenal.90506.2008 [Full Text] [PDF]  

Pál Pacher, Kumar Sharma, György Csordás, Yanqing Zhu, and György Hajnóczky

Uncoupling of ER-mitochondrial calcium communication by transforming growth factor-β
Am J Physiol Renal Physiol 295: F1303-F1312, 2008. First published July 23, 2008; doi:10.1152/ajprenal.90343.2008 [Abstract] [Full Text] [PDF]  

Thomas A. Pressley

The stoichiometry of the Na-K pump: one plus one doesn't equal one
Am J Physiol Renal Physiol 295: F1313-F1313, 2008. First published September 3, 2008; doi:10.1152/ajprenal.90512.2008 [Full Text] [PDF]  

Rebecca J. Clifford and Jack H. Kaplan

β-Subunit overexpression alters the stoicheometry of assembled Na-K-ATPase subunits in MDCK cells
Am J Physiol Renal Physiol 295: F1314-F1323, 2008. First published August 13, 2008; doi:10.1152/ajprenal.90406.2008 [Abstract] [Full Text] [PDF]  

TRANSLATIONAL PHYSIOLOGY:

Elaine M. Worcester, Fredric L. Coe, Andrew P. Evan, Kristin J. Bergsland, Joan H. Parks, Lynn R. Willis, Daniel L. Clark, and Daniel L. Gillen

Evidence for increased postprandial distal nephron calcium delivery in hypercalciuric stone-forming patients
Am J Physiol Renal Physiol 295: F1286-F1294, 2008. First published August 20, 2008; doi:10.1152/ajprenal.90404.2008 [Abstract] [Full Text] [PDF]  

Aleksander Krag, Flemming Bendtsen, Erling Bjerregaard Pedersen, Niels-Henrik Holstein-Rathlou, and Søren Møller

Effects of terlipressin on the aquaretic system: evidence of antidiuretic effects
Am J Physiol Renal Physiol 295: F1295-F1300, 2008. First published August 27, 2008; doi:10.1152/ajprenal.90407.2008 [Abstract] [Full Text] [PDF]  

ARTICLES:

Hsien-Yu Peng, Hung-Ming Chang, Shin-Da Lee, Pei-Chen Huang, Gin-Den Chen, Cheng-Hung Lai, Cheng-Yuan Lai, Chun-Hsien Chiu, Kwong-Chung Tung, and Tzer-Bin Lin

TRPV₁ mediates the uterine capsaicin-induced NMDA NR2B-dependent cross-organ reflex sensitization in anesthetized rats
Am J Physiol Renal Physiol 295: F1324-F1335, 2008. First published July 16, 2008; doi:10.1152/ajprenal.00126.2008 [Abstract] [Full Text] [PDF]  

Nathan W. Blessing, Mitsi A. Blount, Jeff M. Sands, Christopher F. Martin, and Janet D. Klein

Urea transporters UT-A1 and UT-A3 accumulate in the plasma membrane in response to increased hypertonicity
Am J Physiol Renal Physiol 295: F1336-F1341, 2008. First published August 20, 2008; doi:10.1152/ajprenal.90228.2008 [Abstract] [Full Text] [PDF]  

D. C. A. Leite-Dellova, M. Oliveira-Souza, G. Malnic, and M. Mello-Aires

Genomic and nongenomic dose-dependent biphasic effect of aldosterone on Na⁺/H⁺ exchanger in proximal S3 segment: role of cytosolic calcium
Am J Physiol Renal Physiol 295: F1342-F1352, 2008. First published August 20, 2008; doi:10.1152/ajprenal.00048.2008 [Abstract] [Full Text] [PDF]  

Alan M. Weinstein

A mathematical model of distal nephron acidification: diuretic effects
Am J Physiol Renal Physiol 295: F1353-F1364, 2008. First published August 20, 2008; doi:10.1152/ajprenal.90356.2008 [Abstract] [Full Text] [PDF]  

Matthias Wieser, Guido Stadler, Paul Jennings, Berthold Streubel, Walter Pfaller, Peter Ambros, Claus Riedl, Hermann Katinger, Johannes Grillari, and Regina Grillari-Voglauer

hTERT alone immortalizes epithelial cells of renal proximal tubules without changing their functional characteristics
Am J Physiol Renal Physiol 295: F1365-F1375, 2008. First published August 20, 2008; doi:10.1152/ajprenal.90405.2008 [Abstract] [Full Text] [PDF]  

Yasuhiro Otaki, Naoko Miyauchi, Mutsumi Higa, Akira Takada, Takeshi Kuroda, Fumitake Gejyo, Fujio Shimizu, and Hiroshi Kawachi

Dissociation of NEPH1 from nephrin is involved in development of a rat model of focal segmental glomerulosclerosis
Am J Physiol Renal Physiol 295: F1376-F1387, 2008. First published August 20, 2008; doi:10.1152/ajprenal.00075.2008 [Abstract] [Full Text] [PDF]  

John Holian, Weier Qi, Darren J. Kelly, Yuan Zhang, Ellein Mreich, Carol A. Pollock, and Xin-Ming Chen

Role of Krüppel-like factor 6 in transforming growth factor-β1-induced epithelial-mesenchymal transition of proximal tubule cells
Am J Physiol Renal Physiol 295: F1388-F1396, 2008. First published August 27, 2008; doi:10.1152/ajprenal.00055.2008 [Abstract] [Full Text] [PDF]  

Hilde Gaarkeuken, Machiel A. Siezenga, Kim Zuidwijk, Cees van Kooten, Ton J. Rabelink, Mohamed R. Daha, and Stefan P. Berger

Complement activation by tubular cells is mediated by properdin binding
Am J Physiol Renal Physiol 295: F1397-F1403, 2008. First published August 27, 2008; doi:10.1152/ajprenal.90313.2008 [Abstract] [Full Text] [PDF]  

Samir S. El-Dahr, Karam Aboudehen, and Susana Dipp

Bradykinin B₂ receptor null mice harboring a Ser²³-to-Ala substitution in the p53 gene are protected from renal dysgenesis
Am J Physiol Renal Physiol 295: F1404-F1413, 2008. First published August 27, 2008; doi:10.1152/ajprenal.90378.2008 [Abstract] [Full Text] [PDF]  

Zhibin He, Lawrence Lu, Christopher Altmann, Thomas S. Hoke, Danica Ljubanovic, Alkesh Jani, Charles A. Dinarello, Sarah Faubel, and Charles L. Edelstein

Interleukin-18 binding protein transgenic mice are protected against ischemic acute kidney injury
Am J Physiol Renal Physiol 295: F1414-F1421, 2008. First published August 27, 2008; doi:10.1152/ajprenal.90288.2008 [Abstract] [Full Text] [PDF]  

Jonathan H. Clarke, Piers C. Emson, and Robin F. Irvine

Localization of phosphatidylinositol phosphate kinase II in kidney to a membrane trafficking compartment within specialized cells of the nephron
Am J Physiol Renal Physiol 295: F1422-F1430, 2008. First published August 27, 2008; doi:10.1152/ajprenal.90310.2008 [Abstract] [Full Text] [PDF]  

Edilia Tapia, Dolores J. Sánchez-González, Omar N. Medina-Campos, Virgilia Soto, Carmen Ávila-Casado, Claudia M. Martínez-Martínez, Richard J. Johnson, Bernardo Rodríguez-Iturbe, José Pedraza-Chaverrí, Martha Franco, and Laura G. Sánchez-Lozada

Treatment with pyrrolidine dithiocarbamate improves proteinuria, oxidative stress, and glomerular hypertension in overload proteinuria
Am J Physiol Renal Physiol 295: F1431-F1439, 2008. First published August 27, 2008; doi:10.1152/ajprenal.90201.2008 [Abstract] [Full Text] [PDF]  

Nandita S. Raikwar, Peter M. Snyder, and Christie P. Thomas

An evolutionarily conserved N-terminal Sgk1 variant with enhanced stability and improved function
Am J Physiol Renal Physiol 295: F1440-F1448, 2008. First published August 27, 2008; doi:10.1152/ajprenal.90239.2008 [Abstract] [Full Text] [PDF]  

Tracy D. Bell, Gerald F. DiBona, Rachel Biemiller, and Michael W. Brands

Continuously measured renal blood flow does not increase in diabetes if nitric oxide synthesis is blocked
Am J Physiol Renal Physiol 295: F1449-F1456, 2008. First published August 27, 2008; doi:10.1152/ajprenal.00004.2008 [Abstract] [Full Text] [PDF]  

Yasuhisa Kanematsu, Kunihisa Yamaguchi, Hideki Ohnishi, Yuki Motobayashi, Keisuke Ishizawa, Yuki Izawa, Kazuyoshi Kawazoe, Shuji Kondo, Shoji Kagami, Shuhei Tomita, Koichiro Tsuchiya, and Toshiaki Tamaki

Dietary doses of nitrite restore circulating nitric oxide level and improve renal injury in L-NAME-induced hypertensive rats
Am J Physiol Renal Physiol 295: F1457-F1462, 2008. First published August 27, 2008; doi:10.1152/ajprenal.00621.2007 [Abstract] [Full Text] [PDF]  

Darren P. Wallace, Megan T. Quante, Gail A. Reif, Emily Nivens, Farhana Ahmed, Scott J. Hempson, Gustavo Blanco, and Tamio Yamaguchi

Periostin induces proliferation of human autosomal dominant polycystic kidney cells through _V-integrin receptor
Am J Physiol Renal Physiol 295: F1463-F1471, 2008. First published August 27, 2008; doi:10.1152/ajprenal.90266.2008 [Abstract] [Full Text] [PDF]  

Wei Zhang, Tao Na, and Ji-Bin Peng

WNK3 positively regulates epithelial calcium channels TRPV5 and TRPV6 via a kinase-dependent pathway
Am J Physiol Renal Physiol 295: F1472-F1484, 2008. First published September 3, 2008; doi:10.1152/ajprenal.90229.2008 [Abstract] [Full Text] [PDF]  

Hye Kyoung Song, Mi Hwa Lee, Bo Kyung Kim, Yun Gyu Park, Gang Jee Ko, Young Sun Kang, Jee Young Han, Sang Youb Han, Kum Hyun Han, Hyoung Kyu Kim, and Dae Ryong Cha

Visfatin: a new player in mesangial cell physiology and diabetic nephropathy
Am J Physiol Renal Physiol 295: F1485-F1494, 2008. First published September 3, 2008; doi:10.1152/ajprenal.90231.2008 [Abstract] [Full Text] [PDF]  

Maro Okamura, Yosuke Takano, Nobuhiko Hiramatsu, Kunihiro Hayakawa, Jian Yao, Adrienne W. Paton, James C. Paton, and Masanori Kitamura

Suppression of cytokine responses by indomethacin in podocytes: a mechanism through induction of unfolded protein response
Am J Physiol Renal Physiol 295: F1495-F1503, 2008. First published September 17, 2008; doi:10.1152/ajprenal.00602.2007 [Abstract] [Full Text] [PDF]  

Sungmi Park, Benjamin J. Bivona, Yumei Feng, Eric Lazartigues, and Lisa M. Harrison-Bernard

Intact renal afferent arteriolar autoregulatory responsiveness in db/db mice
Am J Physiol Renal Physiol 295: F1504-F1511, 2008. First published August 27, 2008; doi:10.1152/ajprenal.90417.2008 [Abstract] [Full Text] [PDF]  

Naro Ohashi, Tatsuo Yamamoto, Yanjie Huang, Taro Misaki, Hirotaka Fukasawa, Hiroyuki Suzuki, Akashi Togawa, Sayuri Suzuki, Yoshihide Fujigaki, Tsutomu Nakagawa, Yukio Nakamura, Fumiaki Suzuki, Masatoshi Kitagawa, and Akira Hishida

Intrarenal RAS activity and urinary angiotensinogen excretion in anti-thymocyte serum nephritis rats
Am J Physiol Renal Physiol 295: F1512-F1518, 2008. First published September 10, 2008; doi:10.1152/ajprenal.00058.2008 [Abstract] [Full Text] [PDF]  

Ling Yu, My N. Helms, Qiang Yue, and Douglas C. Eaton

Single-channel analysis of functional epithelial sodium channel (ENaC) stability at the apical membrane of A6 distal kidney cells
Am J Physiol Renal Physiol 295: F1519-F1527, 2008. First published September 10, 2008; doi:10.1152/ajprenal.00605.2007 [Abstract] [Full Text] [PDF]  

Guangping Chen, Haidong Huang, Otto Fröhlich, Yuan Yang, Janet D. Klein, S. Russ Price, and Jeff M. Sands

MDM2 E3 ubiquitin ligase mediates UT-A1 urea transporter ubiquitination and degradation
Am J Physiol Renal Physiol 295: F1528-F1534, 2008. First published September 10, 2008; doi:10.1152/ajprenal.90482.2008 [Abstract] [Full Text] [PDF]  

Ryoichi Saiki, Adam L. Lunceford, Yuchen Shi, Beth Marbois, Rhonda King, Justin Pachuski, Makoto Kawamukai, David L. Gasser, and Catherine F. Clarke

Coenzyme Q₁₀ supplementation rescues renal disease in Pdss2^kd/kd mice with mutations in prenyl diphosphate synthase subunit 2
Am J Physiol Renal Physiol 295: F1535-F1544, 2008. First published September 10, 2008; doi:10.1152/ajprenal.90445.2008 [Abstract] [Full Text] [PDF]  

Yasunori Mizuguchi, Jie Chen, Surya V. Seshan, Dix P. Poppas, Hazel H. Szeto, and Diane Felsen

A novel cell-permeable antioxidant peptide decreases renal tubular apoptosis and damage in unilateral ureteral obstruction
Am J Physiol Renal Physiol 295: F1545-F1553, 2008. First published September 10, 2008; doi:10.1152/ajprenal.00395.2007 [Abstract] [Full Text] [PDF]  

Eugenia Vinuesa, Anna Sola, Michaela Jung, Vicente Alfaro, and Georgina Hotter

Lipocalin-2-induced renal regeneration depends on cytokines
Am J Physiol Renal Physiol 295: F1554-F1562, 2008. First published September 24, 2008; doi:10.1152/ajprenal.90250.2008 [Abstract] [Full Text] [PDF]  

Daniela Verzola, Maria Teresa Gandolfo, Gianfranco Gaetani, Annamaria Ferraris, Rosa Mangerini, Franco Ferrario, Barbara Villaggio, Fabio Gianiorio, Fanny Tosetti, Ursula Weiss, Paolo Traverso, Mariano Mji, Giacomo Deferrari, and Giacomo Garibotto

Accelerated senescence in the kidneys of patients with type 2 diabetic nephropathy
Am J Physiol Renal Physiol 295: F1563-F1573, 2008. First published September 3, 2008; doi:10.1152/ajprenal.90302.2008 [Abstract] [Full Text] [PDF]  

Joyce Trujillo, Cristino Cruz, Armando Tovar, Vishal Vaidya, Elena Zambrano, Joseph V. Bonventre, Gerardo Gamba, Nimbe Torres, and Norma A. Bobadilla

Renoprotective mechanisms of soy protein intake in the obese Zucker rat
Am J Physiol Renal Physiol 295: F1574-F1582, 2008. First published September 24, 2008; doi:10.1152/ajprenal.90385.2008 [Abstract] [Full Text] [PDF]  

INNOVATIVE METHODOLOGY:

Christopher Peter Reinhardt, Michael J. Germain, Ernest V. Groman, Jeffrey G. Mulhern, Rajesh Kumar, and Dennis E. Vaccaro

Functional immunoassay technology (FIT), a new approach for measuring physiological functions: application of FIT to measure glomerular filtration rate (GFR)
Am J Physiol Renal Physiol 295: F1583-F1588, 2008. First published September 3, 2008; doi:10.1152/ajprenal.90354.2008 [Abstract] [Full Text] [PDF]  

REVIEWS:

Roger G. Evans, Bruce S. Gardiner, David W. Smith, and Paul M. O'Connor

Intrarenal oxygenation: unique challenges and the biophysical basis of homeostasis
Am J Physiol Renal Physiol 295: F1259-F1270, 2008. First published June 11, 2008; doi:10.1152/ajprenal.90230.2008 [Abstract] [Full Text] [PDF]  

Thomas L. Pannabecker, William H. Dantzler, Harold E. Layton, and Anita T. Layton

Role of three-dimensional architecture in the urine concentrating mechanism of the rat renal inner medulla
Am J Physiol Renal Physiol 295: F1271-F1285, 2008. First published May 21, 2008; doi:10.1152/ajprenal.90252.2008 [Abstract] [Full Text] [PDF]  

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