EDITORIAL FOCUS:

Brian J. Siroky and Markus Bitzer

The growing importance of mTORC1-S6K1 signaling in kidney
Am J Physiol Renal Physiol 297: F583-F584, 2009. First published July 1, 2009; doi:10.1152/ajprenal.00357.2009 [Full Text] [PDF]  

Jian-Kang Chen, Jianchun Chen, George Thomas, Sara C. Kozma, and Raymond C. Harris

S6 kinase 1 knockout inhibits uninephrectomy- or diabetes-induced renal hypertrophy
Am J Physiol Renal Physiol 297: F585-F593, 2009. First published May 27, 2009; doi:10.1152/ajprenal.00186.2009 [Abstract] [Full Text] [PDF]  

TRANSLATIONAL PHYSIOLOGY:

Josefin Axelsson, Irma Mahmutovic, Anna Rippe, and Bengt Rippe

Loss of size selectivity of the glomerular filtration barrier in rats following laparotomy and muscle trauma
Am J Physiol Renal Physiol 297: F577-F582, 2009. First published July 8, 2009; doi:10.1152/ajprenal.00246.2009 [Abstract] [Full Text] [PDF]  

ARTICLES:

Garyfalia I. Drossopoulou, Nikolaos E. Tsotakos, and Effie C. Tsilibary

Impaired transcription factor interplay in addition to advanced glycation end products suppress podocalyxin expression in high glucose-treated human podocytes
Am J Physiol Renal Physiol 297: F594-F603, 2009. First published July 15, 2009; doi:10.1152/ajprenal.00203.2009 [Abstract] [Full Text] [PDF]  

Daniel F. Balkovetz, Phillip Chumley, and Hassane Amlal

Downregulation of claudin-2 expression in renal epithelial cells by metabolic acidosis
Am J Physiol Renal Physiol 297: F604-F611, 2009. First published July 8, 2009; doi:10.1152/ajprenal.00043.2009 [Abstract] [Full Text] [PDF]  

Stéphanie Bibert, Solange Kharoubi Hess, Dmitri Firsov, Bernard Thorens, Käthi Geering, Jean-Daniel Horisberger, and Olivier Bonny

Mouse GLUT9: evidences for a urate uniporter
Am J Physiol Renal Physiol 297: F612-F619, 2009. First published July 8, 2009; doi:10.1152/ajprenal.00139.2009 [Abstract] [Full Text] [PDF]  

Hasiyet Memetimin, Yuichiro Izumi, Yushi Nakayama, Yukimasa Kohda, Hideki Inoue, Hiroshi Nonoguchi, and Kimio Tomita

Low pH stimulates vasopressin V2 receptor promoter activity and enhances downregulation induced by V1a receptor stimulation
Am J Physiol Renal Physiol 297: F620-F628, 2009. First published July 8, 2009; doi:10.1152/ajprenal.90520.2008 [Abstract] [Full Text] [PDF]  

Pu Duann and Elias A. Lianos

GEC-targeted HO-1 expression reduces proteinuria in glomerular immune injury
Am J Physiol Renal Physiol 297: F629-F638, 2009. First published July 8, 2009; doi:10.1152/ajprenal.00213.2009 [Abstract] [Full Text] [PDF]  

Helena Gil-Peña, Enrique Garcia-Lopez, Oscar Alvarez-Garcia, Vanessa Loredo, Eduardo Carbajo-Perez, Flor A. Ordoñez, Julian Rodriguez-Suarez, and Fernando Santos

Alterations of growth plate and abnormal insulin-like growth factor I metabolism in growth-retarded hypokalemic rats: effect of growth hormone treatment
Am J Physiol Renal Physiol 297: F639-F645, 2009. First published July 8, 2009; doi:10.1152/ajprenal.00188.2009 [Abstract] [Full Text] [PDF]  

Guillermo B. Silva and Jeffrey L. Garvin

Akt1 mediates purinergic-dependent NOS3 activation in thick ascending limbs
Am J Physiol Renal Physiol 297: F646-F652, 2009. First published July 1, 2009; doi:10.1152/ajprenal.00270.2009 [Abstract] [Full Text] [PDF]  

Shitij Arora, Mohammad Husain, Dileep Kumar, Hitesh Patni, Shresh Pathak, Devi Mehrotra, Vivek Kathi Reddy, Lalit Rajeev Reddy, Divya Salhan, Anju Yadav, Peter W. Mathieson, Moin A. Saleem, Praveen N. Chander, and Pravin C. Singhal

Human immunodeficiency virus downregulates podocyte apoE expression
Am J Physiol Renal Physiol 297: F653-F661, 2009. First published June 24, 2009; doi:10.1152/ajprenal.90668.2008 [Abstract] [Full Text] [PDF]  

Talha Akbulut, Kevin R. Regner, Richard J. Roman, Ellis D. Avner, John R. Falck, and Frank Park

20-HETE activates the Raf/MEK/ERK pathway in renal epithelial cells through an EGFR- and c-Src-dependent mechanism
Am J Physiol Renal Physiol 297: F662-F670, 2009. First published July 1, 2009; doi:10.1152/ajprenal.00146.2009 [Abstract] [Full Text] [PDF]  

Hiroko Segawa, Akemi Onitsuka, Junya Furutani, Ichiro Kaneko, Fumito Aranami, Natsuki Matsumoto, Yuka Tomoe, Masashi Kuwahata, Mikiko Ito, Mitsuru Matsumoto, Minqi Li, Norio Amizuka, and Ken-ichi Miyamoto

Npt2a and Npt2c in mice play distinct and synergistic roles in inorganic phosphate metabolism and skeletal development
Am J Physiol Renal Physiol 297: F671-F678, 2009. First published July 1, 2009; doi:10.1152/ajprenal.00156.2009 [Abstract] [Full Text] [PDF]  

Mari Tomiyama-Hanayama, Hiromi Rakugi, Masaharu Kohara, Toru Mima, Yasuo Adachi, Mitsuru Ohishi, Tomohiro Katsuya, Yoshihiko Hoshida, Katsuyuki Aozasa, Toshio Ogihara, and Norihiro Nishimoto

Effect of interleukin-6 receptor blockage on renal injury in apolipoprotein E-deficient mice
Am J Physiol Renal Physiol 297: F679-F684, 2009. First published July 1, 2009; doi:10.1152/ajprenal.90680.2008 [Abstract] [Full Text] [PDF]  

Robert Ahlstrom and Alan S. L. Yu

Characterization of the kinase activity of a WNK4 protein complex
Am J Physiol Renal Physiol 297: F685-F692, 2009. First published July 8, 2009; doi:10.1152/ajprenal.00358.2009 [Abstract] [Full Text] [PDF]  

Jens Klokkers, Patrik Langehanenberg, Björn Kemper, Sebastian Kosmeier, Gert von Bally, Christoph Riethmüller, Frank Wunder, Aleksandra Sindic, Hermann Pavenstädt, Eberhard Schlatter, and Bayram Edemir

Atrial natriuretic peptide and nitric oxide signaling antagonizes vasopressin-mediated water permeability in inner medullary collecting duct cells
Am J Physiol Renal Physiol 297: F693-F703, 2009. First published July 1, 2009; doi:10.1152/ajprenal.00136.2009 [Abstract] [Full Text] [PDF]  

Volker Vallon, Jana Schroth, Florian Lang, Dietmar Kuhl, and Shinichi Uchida

Expression and phosphorylation of the Na⁺-Cl^– cotransporter NCC in vivo is regulated by dietary salt, potassium, and SGK1
Am J Physiol Renal Physiol 297: F704-F712, 2009. First published July 1, 2009; doi:10.1152/ajprenal.00030.2009 [Abstract] [Full Text] [PDF]  

Vardit Lavi-Moshayoff, Justin Silver, and Tally Naveh-Many

Human PTH gene regulation in vivo using transgenic mice
Am J Physiol Renal Physiol 297: F713-F719, 2009. First published July 1, 2009; doi:10.1152/ajprenal.00161.2009 [Abstract] [Full Text] [PDF]  

Ogo Egbuna, Steven Quinn, Lakshmi Kantham, Robert Butters, Jiang Pang, Martin Pollak, David Goltzman, and Edward Brown

The full-length calcium-sensing receptor dampens the calcemic response to 1,25(OH)₂ vitamin D₃ in vivo independently of parathyroid hormone
Am J Physiol Renal Physiol 297: F720-F728, 2009. First published May 27, 2009; doi:10.1152/ajprenal.00164.2009 [Abstract] [Full Text] [PDF]  

Hyunjin Noh, Eun Young Oh, Ji Yeon Seo, Mi Ra Yu, Young Ok Kim, Hunjoo Ha, and Hi Bahl Lee

Histone deacetylase-2 is a key regulator of diabetes- and transforming growth factor-β1-induced renal injury
Am J Physiol Renal Physiol 297: F729-F739, 2009. First published June 24, 2009; doi:10.1152/ajprenal.00086.2009 [Abstract] [Full Text] [PDF]  

Marlina Manhiani, Jeffrey E. Quigley, Sarah F. Knight, Shiva Tasoobshirazi, TarRhonda Moore, Michael W. Brands, Bruce D. Hammock, and John D. Imig

Soluble epoxide hydrolase gene deletion attenuates renal injury and inflammation with DOCA-salt hypertension
Am J Physiol Renal Physiol 297: F740-F748, 2009. First published June 24, 2009; doi:10.1152/ajprenal.00098.2009 [Abstract] [Full Text] [PDF]  

Kishor Devalaraja-Narashimha, Alicia M. Diener, and Babu J. Padanilam

Cyclophilin D gene ablation protects mice from ischemic renal injury
Am J Physiol Renal Physiol 297: F749-F759, 2009. First published June 24, 2009; doi:10.1152/ajprenal.00239.2009 [Abstract] [Full Text] [PDF]  

Andrea Havasi, Zhiyong Wang, Jonathan M. Gall, Max Spaderna, Vikram Suri, Ellery Canlas, Jody L. Martin, John H. Schwartz, and Steven C. Borkan

Hsp27 inhibits sublethal, Src-mediated renal epithelial cell injury
Am J Physiol Renal Physiol 297: F760-F768, 2009. First published June 24, 2009; doi:10.1152/ajprenal.00052.2009 [Abstract] [Full Text] [PDF]  

Matthias Schaier, Stefanie Vorwalder, Claudia Sommerer, Ralf Dikow, Friederike Hug, Marie-Luise Gross, Rüdiger Waldherr, and Martin Zeier

Role of FTY720 on M1 and M2 macrophages, lymphocytes, and chemokines in nephrectomized rats
Am J Physiol Renal Physiol 297: F769-F780, 2009. First published June 17, 2009; doi:10.1152/ajprenal.90530.2008 [Abstract] [Full Text] [PDF]  

W. B. Melenhorst, L. Visser, A. Timmer, M. C. van den Heuvel, C. A. Stegeman, and H. van Goor

ADAM17 upregulation in human renal disease: a role in modulating TGF- availability?
Am J Physiol Renal Physiol 297: F781-F790, 2009. First published June 17, 2009; doi:10.1152/ajprenal.90610.2008 [Abstract] [Full Text] [PDF]  

Yan Zhang, Dilip K. Deb, Juan Kong, Gang Ning, Yurong Wang, George Li, Yunzi Chen, Zhongyi Zhang, Stephen Strugnell, Yves Sabbagh, Cynthia Arbeeny, and Yan Chun Li

Long-term therapeutic effect of vitamin D analog doxercalciferol on diabetic nephropathy: strong synergism with AT₁ receptor antagonist
Am J Physiol Renal Physiol 297: F791-F801, 2009. First published June 17, 2009; doi:10.1152/ajprenal.00247.2009 [Abstract] [Full Text] [PDF]  

Jun Du, Yu-Yan Fan, Hirofumi Hitomi, Hideyasu Kiyomoto, Shoji Kimura, Chui-Ze Kong, Takahisa Noma, Masakazu Kohno, Akira Nishiyama, and Daisuke Nakano

Mineralocorticoid receptor blockade and calcium channel blockade have different renoprotective effects on glomerular and interstitial injury in rats
Am J Physiol Renal Physiol 297: F802-F808, 2009. First published June 17, 2009; doi:10.1152/ajprenal.00197.2009 [Abstract] [Full Text] [PDF]  

Derek C. Adams and Leif Oxburgh

The long-term label retaining population of the renal papilla arises through divergent regional growth of the kidney
Am J Physiol Renal Physiol 297: F809-F815, 2009. First published June 17, 2009; doi:10.1152/ajprenal.90650.2008 [Abstract] [Full Text] [PDF] [Supplemental Figures]  

Stephanie Tseng-Rogenski and Monica Liebert

Interleukin-8 is essential for normal urothelial cell survival
Am J Physiol Renal Physiol 297: F816-F821, 2009. First published June 17, 2009; doi:10.1152/ajprenal.90733.2008 [Abstract] [Full Text] [PDF]  

D. Wu, F. Peng, B. Zhang, A. J. Ingram, D. J. Kelly, R. E. Gilbert, B. Gao, S. Kumar, and J. C. Krepinsky

EGFR-PLC1 signaling mediates high glucose-induced PKCβ1-Akt activation and collagen I upregulation in mesangial cells
Am J Physiol Renal Physiol 297: F822-F834, 2009. First published July 15, 2009; doi:10.1152/ajprenal.00054.2009 [Abstract] [Full Text] [PDF]  

LETTERS TO THE EDITOR:

Michal Chmielewski and Boleslaw Rutkowski

Mechanisms of dyslipidemia in chronic kidney disease
Am J Physiol Renal Physiol 297: F835-F835, 2009; doi:10.1152/ajprenal.00269.2009 [Full Text] [PDF]  

REVIEWS:

Mingyu Liang, Yong Liu, Domagoj Mladinov, Allen W. Cowley, Jr., Hariprasad Trivedi, Yi Fang, Xialian Xu, Xiaoqiang Ding, and Zhongmin Tian

MicroRNA: a new frontier in kidney and blood pressure research
Am J Physiol Renal Physiol 297: F553-F558, 2009. First published April 1, 2009; doi:10.1152/ajprenal.00045.2009 [Abstract] [Full Text] [PDF]  

Joel C. Geerling and Arthur D. Loewy

Aldosterone in the brain
Am J Physiol Renal Physiol 297: F559-F576, 2009. First published March 4, 2009; doi:10.1152/ajprenal.90399.2008 [Abstract] [Full Text] [PDF]  

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